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\/>\n\u79fb\u690d\u7247\u5bfe\u5bbf\u4e3b\u75c5\uff08GVHD\uff09\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u60a3\u8005\u3055\u3093\u3068\u30c9\u30ca\u30fc\u306e\u65b9\u306e\u767d\u8840\u7403\u306e\u578b\uff08\u7d44\u7e54\u9069\u5408\u6297\u539f\u3001HLA\u3068\u547c\u3073\u307e\u3059\uff09\u3092\u53ef\u80fd\u306a\u9650\u308a\u5408\u308f\u305b\u3066\u304b\u3089\u79fb\u690d\u3092\u884c\u3046\u306e\u304c\u4e00\u822c\u7684\u3067\u3059\u3002HLA\u3092\u5408\u308f\u305b\u308b\u7406\u7531\u306f\u3001\u30ea\u30f3\u30d1\u7403\u304cHLA\u306e\u9055\u3044\u3092\u6700\u3082\u92ed\u654f\u306a\u6307\u6a19\u306b\u3057\u3066\u3001\u305d\u306e\u7d30\u80de\u304c\u3088\u305d\u8005\u304b\u5426\u304b\u3092\u533a\u5225\u3059\u308b\u304b\u3089\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30ea\u30f3\u30d1\u7403\u306f\u9ad8\u5ea6\u306b\u8a13\u7df4\u3055\u308c\u305f\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u3067\u3042\u308b\u305f\u3081\u3001HLA\u4ee5\u5916\u306e\u60a3\u8005\u2010\u30c9\u30ca\u30fc\u9593\u306e\u5fae\u5999\u306a\u9055\u3044\u3082\u8a8d\u8b58\u3057\u307e\u3059\u3002\u30d2\u30c8\u306e\u4f53\u3092\u69cb\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3064\u304f\u308a\u51fa\u3059\u3082\u3068\u3068\u306a\u308b\u907a\u4f1d\u5b50\u306b\u306f\u3001\u500b\u4eba\u306b\u3088\u308b\u591a\u69d8\u6027\uff08\u3053\u308c\u3092SNP\uff08\u30b9\u30cb\u30c3\u30d7\uff09\u3068\u3044\u3044\u307e\u3059\uff09\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u69cb\u6210\u3059\u308b\u30a2\u30df\u30ce\u9178\u306e\u4e26\u3073\u65b9\u306b\u3082\u5c0f\u3055\u306a\u9055\u3044\u304c\u767a\u751f\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u3088\u3046\u306a\u3001\u500b\u3005\u306e\u30d2\u30c8\u3067\u76f8\u9055\u3059\u308b\u30a2\u30df\u30ce\u9178\u306e\u4e26\u3073\u65b9\u3092\u30ea\u30f3\u30d1\u7403\u304c\u8b58\u5225\u3057\u3066\u53cd\u5fdc\u3059\u308b\u3053\u3068\u3092\u3001\u300c\u30de\u30a4\u30ca\u30fc\u7d44\u7e54\u9069\u5408\u6027\u6297\u539f\u300d\u3068\u547c\u3093\u3067\u3044\u307e\u3059\u3002HLA\u3092\u53b3\u5bc6\u306b\u5408\u308f\u305b\u305f\u540c\u80de\u9593\u3067\u3082GVHD\u304c\u307f\u3089\u308c\u308b\u306e\u306f\u3001\u3053\u306e\u30de\u30a4\u30ca\u30fc\u7d44\u7e54\u9069\u5408\u6027\u6297\u539f\u306e\u76f8\u9055\u306b\u3088\u308b\u3082\u306e\u3067\u3059\u3002\u30d2\u30c8\u306e\u30de\u30a4\u30ca\u30fc\u7d44\u7e54\u9069\u5408\u6027\u6297\u539f\u306f\u3001\u6570\u767e\u7a2e\u3042\u308b\u3068\u63a8\u5b9a\u3055\u308c\u307e\u3059\u3002\u500b\u3005\u4eba\u306e\u9593\u3067\u610f\u5473\u306e\u3042\u308b\u30de\u30a4\u30ca\u30fc\u7d44\u7e54\u9069\u5408\u6027\u6297\u539f\u306f\u7570\u306a\u308a\u3001\u305d\u308c\u305e\u308c\u306eHLA\u306b\u7279\u6709\u306e\u30de\u30a4\u30ca\u30fc\u7d44\u7e54\u9069\u5408\u6027\u6297\u539f\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u2010\u30c9\u30ca\u30fc\u9593\u3067\u500b\u3005\u306b\u30de\u30a4\u30ca\u30fc\u7d44\u7e54\u9069\u5408\u6027\u6297\u539f\u3092\u9069\u5408\u3055\u305b\u308b\u3053\u3068\u306f\u975e\u5e38\u306b\u56f0\u96e3\u3067\u3001GVHD\u304c\u3069\u3046\u3057\u3066\u3082\u4e00\u5b9a\u306e\u78ba\u7387\u3067\u751f\u3058\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u6700\u8fd1\u3067\u306f\u3001\u65e5\u672c\u4eba\u306b\u3088\u304f\u307f\u3089\u308c\u308bHLA\u578b\u306b\u95a2\u9023\u3059\u308b\u30de\u30a4\u30ca\u30fc\u7d44\u7e54\u9069\u5408\u6297\u539f\u304c\u3001\u8907\u6570\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\n\uff16\uff0e\u79fb\u690d\u7247\u5bfe\u5bbf\u4e3b\u75c5\uff08GVHD\uff09\u306f\u4e88\u9632\u53ef\u80fd\u304b<br 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\/>\n\u5b9f\u969b\u306e\u79fb\u690d\u73fe\u5834\u3067\u306fGVHD\u4e88\u9632\u306e\u305f\u3081\u3001\u79fb\u690d\u65e5\u524d\u5f8c\u304b\u3089\u9577\u671f\u9593\u3001\u514d\u75ab\u3092\u6291\u3048\u308b\u85ac\u5264\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002\u6700\u3082\u591a\u304f\u4f7f\u308f\u308c\u308bGVHD\u4e88\u9632\u6cd5\u306f\u3001\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3042\u308b\u3044\u306f\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u306b\u3001\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u3092\u4f75\u7528\u3057\u305f\u65b9\u6cd5\u3067\u3059\u3002\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306f\u3001\u6b27\u7c73\u3067\u306f\u79fb\u690d\u5f8c\uff11\u3001\uff13\u3001\uff16\u300111\u65e5\u76ee\u306b\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\u3002\u91cd\u75c7\u306e\u6025\u6027GVHD\u306e\u983b\u5ea6\u304c\u5c11\u306a\u3044\u65e5\u672c\u3067\u306f\u3001\u53e3\u8154\u7c98\u819c\u306e\u969c\u5bb3\u3084\u9aa8\u9ac4\u56de\u5fa9\u3078\u306e\u5f71\u97ff\u3092\u61f8\u5ff5\u3057\u3066\u300111\u65e5\u76ee\u3092\u7701\u3044\u305f\u65b9\u6cd5\u3082\u3088\u304f\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3084\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u306e\u6295\u4e0e\u91cf\u306f\u3001\u6709\u52b9\u3067\u5b89\u5168\u306b\u4f7f\u7528\u3067\u304d\u308b\u8840\u4e2d\u6fc3\u5ea6\u304c\u7dad\u6301\u3067\u304d\u308b\u3088\u3046\u306b\u3001\u9031\u306b\uff12\uff5e\uff13\u56de\u7a0b\u5ea6\u3001\u8840\u4e2d\u6fc3\u5ea6\u3092\u8abf\u3079\u308b\u305f\u3081\u306e\u63a1\u8840\u3092\u884c\u3063\u3066\u8abf\u7bc0\u3057\u307e\u3059\u3002\u8840\u4e2d\u6fc3\u5ea6\u304c\u4f4e\u3051\u308c\u3070\u6025\u6027GVHD\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u3001\u9ad8\u3059\u304e\u308b\u3068\u814e\u969c\u5bb3\u306a\u3069\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u5185\u670d\u6295\u4e0e\u3084\u5206\u5272\u70b9\u6ef4\u6295\u4e0e\u306e\u5834\u5408\u306b\u306f\u3001\u6b21\u306e\u85ac\u5264\u6295\u4e0e\u76f4\u524d\u306b\u63a1\u8840\u3057\u3066\u8840\u4e2d\u6fc3\u5ea6\u304c\u6700\u4f4e\u3068\u306a\u308b\u3068\u304d\u306e\u8840\u4e2d\u6fc3\u5ea6\uff08\u30c8\u30e9\u30d5\u5024\uff09\u3092\u6307\u6a19\u3068\u3059\u308b\u306e\u304c\u4e00\u822c\u7684\u3067\u3059\u3002\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3042\u308b\u3044\u306f\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u306f\u3001\u6025\u6027GVHD\u304c\u306a\u3051\u308c\u3070\u539f\u5247\u3068\u3057\u3066\u79fb\u690d\u5f8c\uff12\uff5e\uff14\u30f5\u6708\u76ee\u3053\u308d\u304b\u3089\u3086\u3063\u304f\u308a\u6e1b\u91cf\u3057\u3066\u3044\u304d\u307e\u3059\u304c\u3001\u6e1b\u91cf\u306e\u901f\u5ea6\u306f\u526f\u4f5c\u7528\u304c\u51fa\u3084\u3059\u3044\u304b\u3069\u3046\u304b\u3001\u518d\u767a\u3057\u3084\u3059\u3044\u304b\u3069\u3046\u304b\u306a\u3069\u3082\u8003\u616e\u3057\u3064\u3064\u3001\u500b\u5225\u7684\u306b\u5224\u65ad\u3055\u308c\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\u3002\u307e\u305f\u3001\u4e2d\u6b62\u306e\u6642\u671f\u306b\u95a2\u3057\u3066\u306f\u3001\u6162\u6027GVHD\u304c\u51fa\u73fe\u3057\u306a\u3051\u308c\u3070\u3001\u79fb\u690d\u5f8c180\u65e5\u524d\u5f8c\u304c\u76ee\u6a19\u3068\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3088\u3046\u3067\u3059\u3002\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3084\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u306e\u526f\u4f5c\u7528\u306b\u306f\u3001\u814e\u969c\u5bb3\u306e\u4ed6\u306b\u4e2d\u67a2\u795e\u7d4c\u969c\u5bb3\uff08\u3051\u3044\u308c\u3093\u3001\u8996\u529b\u969c\u5bb3\u3001\u610f\u8b58\u306e\u6df7\u6fc1\uff08\u3053\u3093\u3060\u304f\uff09\u7b49\uff09\u3001\u9ad8\u8840\u5727\u3001\u3080\u304f\u307f\uff08\u6d6e\u816b\uff08\u3075\u3057\u3085\uff09\uff09\u3001\u5fae\u5c0f\u8840\u7ba1\u969c\u5bb3\u3001\u9ad8\u8840\u7cd6\u3001\u591a\u6bdb\u7b49\u304c\u3042\u308a\u307e\u3059\u3002\u4ed6\u306e\u85ac\u5264\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3082\u591a\u304f\u3001\u8840\u4e2d\u6fc3\u5ea6\u306b\u5f71\u97ff\u3057\u814e\u6bd2\u6027\u3092\u5897\u5f37\u3057\u307e\u3059\u306e\u3067\u3001\u4f75\u7528\u85ac\u5264\u306b\u3064\u3044\u3066\u306f\u4e3b\u6cbb\u533b\u3068\u3088\u304f\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306f\u85ac\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u9ad8\u304f\u3057\u307e\u3059\u306e\u3067\u63a7\u3048\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3068\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u306e\u3069\u3061\u3089\u3092\u7528\u3044\u308b\u304b\u306f\u3001\u60a3\u8005\u3055\u3093\u3054\u3068\u306b\u6c7a\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e21\u8005\u3092\u6bd4\u8f03\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u306a\u3069\u306e\u7d50\u679c\u3001\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u306e\u307b\u3046\u304c\u6025\u6027GVHD\u3092\u6291\u3048\u308b\u529b\u306f\u5f37\u3044\u3053\u3068\u304c\u5224\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u751f\u5b58\u7387\u306b\u306f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<\/p>\n<p>\n\uff18\uff0e\u6025\u6027\u79fb\u690d\u7247\u5bfe\u5bbf\u4e3b\u75c5\uff08\u6025\u6027GVHD\uff09\u306e\u767a\u75c7\u983b\u5ea6<br \/>\n\u65e5\u672c\u9020\u8840\u7d30\u80de\u79fb\u690d\u5b66\u4f1a\u306e\u96c6\u8a08\u30c7\u30fc\u30bf\u306b\u3088\u308b\u3068\u3001III\u5ea6\u4ee5\u4e0a\u306e\u91cd\u75c7\u306e\u6025\u6027GVHD\u306f\u3001HLA\u9069\u5408\u540c\u80de\u9593\u79fb\u690d\u3067\u306f\u7d04\uff18\uff05\u306b\u3001HLA\u9069\u5408\u975e\u8840\u7e01\u8005\u79fb\u690d\u3067\u306f\u7d0413\uff05\u306b\u8d77\u3053\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u30594)\u3002\u6b27\u7c73\u3067\u306e\u79fb\u690d\u6210\u7e3e\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u65e5\u672c\u4eba\u3067\u306fGVHD\u304c\u6bd4\u8f03\u7684\u8efd\u75c7\u306b\u3068\u3069\u307e\u308b\u5834\u5408\u304c\u591a\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u5e74\u9f62\u304c\u9ad8\u3044\u307b\u3069\u91cd\u75c7GVHD\u306e\u983b\u5ea6\u306f\u9ad8\u304f\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u975e\u8840\u7e01\u8005\u9593\u79fb\u690d\u4f8b\u3067\u306f\u305d\u306e\u5f71\u97ff\u304c\u5c11\u306a\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u79fb\u690d\u7247\u306b\u3088\u308b\u9055\u3044\u3082\u5927\u304d\u304f\u3001\u672b\u68a2\u8840\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f\u5834\u5408\u306f\u767a\u75c7\u983b\u5ea6\u304c\u9ad8\u304f\u3001\u81cd\u5e2f\u8840\u79fb\u690d\u3067\u306f\u4f4e\u304f\u3001\u7279\u306bHLA\u4e0d\u9069\u5408\u3092\u542b\u3080\u81cd\u5e2f\u8840\u79fb\u690d\u306b\u304a\u3051\u308bIII\u5ea6\u4ee5\u4e0a\u306e\u91cd\u75c7\u6025\u6027GVHD\u306e\u983b\u5ea6\u306f\u7d04\uff18\uff05\u3067\u30594)\u3002<\/p>\n<p>GVHD\u306e\u6fc0\u3057\u3055\u306e\u7a0b\u5ea6\uff08\u91cd\u75c7\u5ea6\uff09\u306f\u3001\u75c7\u72b6\u304c\u73fe\u308c\u3066\u3044\u308b\u5668\u5b98\u306e\u6570\u3068\u3069\u306e\u7a0b\u5ea6\u307e\u3067\u305d\u306e\u5668\u5b98\u304c\u4fb5\u3055\u308c\u3066\u3044\u308b\u304b\u3092\u3082\u3068\u306b\u5224\u65ad\u3057\u3001\u6025\u6027GVHD\u306f\u8efd\u5ea6\uff08I\u5ea6\uff09\u3001\u4e2d\u7b49\u5ea6\uff08II\u5ea6\uff09\u3001\u91cd\u5ea6\uff08III\u5ea6\uff09\u3068\u5371\u967a\u57df\uff08IV\u5ea6\uff09\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002\u4e16\u754c\u306e\u56fd\u3005\u306b\u304a\u3044\u3066\u3001\u540c\u4e00\u306e\u57fa\u6e96\u3067\u6025\u6027GVHD\u306e\u91cd\u75c7\u5ea6\u3092\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002\u65e5\u672c\u9020\u8840\u7d30\u80de\u79fb\u690d\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3082\u3001\u305d\u308c\u306b\u5f93\u3063\u3066\u4f5c\u6210\u3055\u308c\u3066\u3044\u307e\u30595)\u3002<\/p>\n<p>\n\uff19\uff0e\u6025\u6027\u79fb\u690d\u7247\u5bfe\u5bbf\u4e3b\u75c5\uff08\u6025\u6027GVHD\uff09\u306e\u75c7\u72b6<br 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