{"id":117,"date":"2008-06-19T20:23:23","date_gmt":"2008-06-19T11:23:23","guid":{"rendered":"http:\/\/haruko.km2m.net\/2008\/06\/19\/%e3%81%8a%e5%af%bf%e5%8f%b8%e3%82%92%e9%a3%9f%e3%81%b9%e3%82%89%e3%82%8c%e3%81%aa%e3%81%84%ef%bc%9f\/"},"modified":"2008-06-19T20:23:23","modified_gmt":"2008-06-19T11:23:23","slug":"%e3%81%8a%e5%af%bf%e5%8f%b8%e3%82%92%e9%a3%9f%e3%81%b9%e3%82%89%e3%82%8c%e3%81%aa%e3%81%84%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/haruko.km2m.net\/?p=117","title":{"rendered":"\u304a\u5bff\u53f8\u3092\u98df\u3079\u3089\u308c\u306a\u3044\uff1f"},"content":{"rendered":"

\u304a\u5bff\u53f8\u3092\u98df\u3079\u3089\u308c\u306a\u3044\uff1f<\/p>\n

\n\u3000\u9aa8\u9ac4\u79fb\u690d\u306e\u6b74\u53f2\u306f\u5b8c\u5168\u7121\u83cc\u5316\u306b\u59cb\u307e\u308a\u307e\u3059\u3002\u4e3b\u6cbb\u533b\u306f\u57fa\u672c\u306b\u5fe0\u5b9f\u306b\u5b8c\u5168\u9632\u5fa1\u3057\u3066\u5b87\u5b99\u670d\u306e\u3088\u3046\u306a\u683c\u597d\u3067\u6e05\u6f54\u3092\u5b88\u308a\uff0c\u5f53\u7136\u306e\u3088\u3046\u306b\u79fb\u690d\u3092\u53d7\u3051\u308b\u5074\u3082\u7121\u83cc\u306e\u305f\u3081\u3068\u79f0\u3057\u3066\u30d2\u30d3\u30c6\u30f3\u306e\u304a\u98a8\u5442\u306b\u5165\u3063\u3066\u304b\u3089\u79fb\u690d\u75c5\u5ba4\u306b\u79fb\u52d5\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u7d0410\u5e74\u524d\u3067\u3059\u3002\u305d\u308c\u304c\u79fb\u690d\u524d\u306e\u901a\u5e38\u3067\u3057\u305f\u3002\u4eca\u306f\u7c21\u6613\u5316\u304c\u76ee\u6a19\u3067\u3059\u3002\u3064\u307e\u308a\uff0c\u624b\u6d17\u3044\u306f\u3057\u3063\u304b\u308a\u3002\uff11m\u4ee5\u5185\u306b\u7acb\u3061\u5165\u3089\u306a\u3051\u308c\u3070\uff0c\u30de\u30b9\u30af\u3082\u5fc5\u8981\u3067\u306f\u306a\u3044\u3002\u65b0\u805e\uff0c\u96d1\u8a8c\u306f\u6301\u3061\u8fbc\u307f\u53ef\u3002\u30da\u30c3\u30c8\u30dc\u30c8\u30eb\u3082\u53ef\u3002\u65e5\u5e38\u306e\u7740\u66ff\u3048\u3082\u304d\u3061\u3093\u3068\u6d17\u6fef\u3055\u308c\u3066\u3044\u308c\u3070\u305d\u306e\u307e\u307e\u75c5\u5ba4\u3078\u3002\u8178\u5185\u7d30\u83cc\u53e2\u3092\u4e71\u3055\u306a\u3044\u3088\u3046\u4e0d\u5fc5\u8981\u306a\u8178\u7ba1\u6ec5\u83cc\u306f\u884c\u308f\u306a\u3044\u3002\u3082\u3061\u308d\u3093\u30d2\u30d3\u30c6\u30f3\u306e\u304a\u98a8\u5442\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u3067\u306f\uff0c\u7c21\u6613\u5316\u306e\u4e2d\u3067\uff0c\u306a\u305c\uff0c\u304a\u5bff\u53f8\u306f\u3060\u3081\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u304a\u5bff\u53f8\u306f\u3060\u3081\uff1f
\n\u3000\u4eac\u5927\u75c5\u9662\u611f\u67d3\u5236\u5fa1\u90e8\u306eDr.\u85e4\u539f\u5c1a\u5b50\u5148\u751f\u306b \u300e\u597d\u4e2d\u7403\u6e1b\u5c11\u6642\u300f \u306e\u98df\u4e8b\u5168\u822c\u306b\u3064\u3044\u3066\u30b3\u30e1\u30f3\u30c8\u3057\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002<\/p>\n

\n\u3000\uff11\uff0e\u539f\u5247\u3068\u3057\u3066\u8840\u6db2\u60aa\u6027\u75be\u60a3\u306e\u5316\u5b66\u7642\u6cd5\u4e2d\u3068\u9020\u8840\u7d30\u80de\u79fb\u690d\u5f8c\u306e\u597d\u4e2d\u7403\u6e1b\u5c11\u6642\u671f\u3092\u5206\u3051\u3066\u8003\u3048\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u79fb\u690d\u5f8c\u306f\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u306b\u5bfe\u3057\u3066\u5236\u7d04\u304c\u3042\u308a\u307e\u3059\uff08\u6587\u732e\uff11\uff09\u3002\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u30b8\u30e5\u30fc\u30b9\u306b\u542b\u307e\u308c\u308b\u30d5\u30e9\u30ce\u30af\u30de\u30ea\u30f3\u8a98\u5c0e\u4f53\u304c\u30c1\u30c8\u30af\u30ed\u30e0P450\u306b\u5bfe\u3059\u308b\u6291\u5236\u52b9\u679c\u3092\u6301\u3064\u305f\u3081\uff0c\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002<\/p>\n

\u3000\uff12\uff0e\u300e\u597d\u4e2d\u7403\u6e1b\u5c11\u6642\u300f\u306e\u60a3\u8005\u3055\u3093\u306e\u591a\u304f\u306f\uff0c\u597d\u4e2d\u7403\u6e1b\u5c11\u3068\u3044\u3046\u30ea\u30b9\u30af\u306b\u52a0\u3048\u3066\uff0c\u514d\u75ab\u6291\u5236\u5264\u6295\u4e0e\u4e2d\u3067\uff0c\u6297\u764c\u5264\u306b\u3088\u308b\u8178\u7ba1\u7c98\u819c\u969c\u5bb3\u304c\u3042\u308a\uff0c\u5e83\u57df\u6297\u83cc\u85ac\u306b\u3088\u308b\u6b63\u5e38\u8178\u5185\u7d30\u83cc\u53e2\u306e\u7834\u7dbb\u304c\u8d77\u3053\u3063\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u5236\u9178\u5264\u6295\u4e0e\u306b\u3088\u308a\u80c3\u9178\u306b\u3088\u308b\u83cc\u91cf\u4f4e\u4e0b\u304c\u898b\u8fbc\u3081\u307e\u305b\u3093\u3002
\n\u3000\u3000\u3000\u3053\u306e\u3088\u3046\u306a\u72b6\u6cc1\u3067\u907f\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b\u98df\u7269\u306f<\/p>\n

\u3000\uff081\uff09\u5065\u5e38\u4eba\u3067\u3082\u907f\u3051\u308b\u3079\u304d\u3082\u306e\uff08\u671f\u9650\u5207\u308c\uff0c\u98df\u4e2d\u6bd2\u304c\u61f8\u5ff5\u3055\u308c\u308b\u98df\u7269\uff09
\n\u3000\uff082\uff09\u6c5a\u67d3\u7d30\u83cc\u30fb\u771f\u83cc\u306e\u91cf\u304c\u591a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3082\u306e\uff0c\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u3000\u3000\u3000\uff081\uff09\u306f\uff0c\u6442\u53d6\u3057\u305f\u5834\u5408\u306e\u8178\u708e\u767a\u75c7\u306e\u95be\u5024\u306e\u4f4e\u3055\uff0c\u304a\u3088\u3073\u767a\u75c7\u6642\u306e\u91cd\u75c7\u5316\u304c\uff0c\u907f\u3051\u308b\u7406\u7531\u3067\u3059\u3002\u5f53\u9662\u3067\u3082\u3088\u304f\u7d4c\u9a13\u3059\u308b\u306e\u306f\uff0c\u30b9\u30c6\u30ed\u30a4\u30c9\u5185\u670d\u4e2d\u306e\u60a3\u8005\u306b\u304a\u3051\u308b\u30b5\u30eb\u30e2\u30cd\u30e9\u8178\u708e\u30fb\u83cc\u8840\u75c7\u3067\u3059\u3002\u901a\u5e38\uff0c\u79c1\u305f\u3061\u5065\u5e38\u4eba\u3082\u65e5\u3005\u30b5\u30eb\u30e2\u30cd\u30e9\u3092\u7d4c\u53e3\u6442\u53d6\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u304c\uff0c\u80c3\u9178\u3067\u306e\u6bba\u83cc\u3084\u8178\u7ba1\u7c98\u819c\u306e\u514d\u75ab\u7b49\u3067\u767a\u75c7\u306b\u81f3\u308b\u3053\u3068\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u306e\u3060\u3068\u8003\u3048\u308b\u306e\u304c\u81ea\u7136\u3067\u3059\u3002\u305d\u308c\u304c\u767a\u75c7\u3057\u3066\u3057\u307e\u3046\u306e\u304c\uff0c\u3053\u3046\u3044\u3046\u60a3\u8005\u3067\u3059\u3002\u307e\u305f\uff0cHIV\u60a3\u8005\u3067\u6709\u540d\u3067\u3059\u304c\uff0c\u767a\u75c7\u5f8c\u306e\u6162\u6027\u5316\uff0c\u518d\u71c3\u3082\u8840\u6db2\u75be\u60a3\u3067\u306e\u5316\u5b66\u7642\u6cd5\u4e2d\u60a3\u8005\u3084\u79fb\u690d\u5f8c\u60a3\u8005\u3067\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u5185\u5bc4\u751f\u6027\u3067\u3042\u308b\u305f\u3081\u306b\u304a\u3053\u308b\u75c5\u614b\u306a\u306e\u3067\uff0c\u4ed6\u306e\u83cc\u306b\u3064\u3044\u3066\u306f\u305d\u306e\u75c5\u614b\u306b\u9855\u8457\u306a\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3002\u6442\u53d6\u6a5f\u4f1a\u3082\u5727\u5012\u7684\u306b\u591a\u3044\u306e\u3067\uff0c\u30b5\u30eb\u30e2\u30cd\u30e9\u306b\u306f\u8981\u6ce8\u610f\u3067\u3059\u3002
\n\u3000\u3000\u3000\uff082\uff09\u306f\uff0c\u6442\u53d6\u3057\u305f\u83cc\u306e\u8178\u7ba1\u75c5\u539f\u6027\u306f\u4e0d\u660e\u3067\u3082\uff0c\u8178\u7ba1\u304b\u3089translocation\u3057\u3066\u83cc\u8840\u75c7\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\uff0c\u907f\u3051\u308b\u7406\u7531\u3067\u3059\u3002\u3082\u306e\u306b\u3088\u3063\u3066\u306f\u6d41\u6c34\u3067\u306e\u6d17\u6d44\u30fb\u52a0\u71b1\u30fb\u4f4e\u6e29\u6bba\u83cc\u3092\u884c\u3063\u3066\u83cc\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u308c\u3070\u6442\u53d6\u53ef\u80fd\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u51e6\u7f6e\u304c\u3067\u304d\u306a\u3044\u3082\u306e\uff08\u81ea\u5bb6\u88fd\u6f2c\u3051\u7269\u30fb\u3082\u3068\u3082\u3068\u751f\u3067\u98df\u3079\u308b\u98df\u7269\uff09\u306f\u907f\u3051\u308b\u3079\u304d\u3082\u306e\u3068\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u30ad\u30e0\u30c1\u306f\uff082\uff09\u306b\u5c5e\u3059\u308b\u305f\u3081\uff0c\u52a0\u71b1\u306b\u3088\u308a\u6442\u53d6\u53ef\u80fd\u3067\u3059\u3002
\n\u3000\u3000\u3000 \u300c\u7121\u83cc\u98df\u300d \u306a\u308b\u3082\u306e\u306f\u4e0d\u8981\u3067\u3059\u304c\uff0c\uff081\uff09\uff082\uff09\u304c\u7591\u308f\u308c\u308b\u98df\u3079\u7269\u306f\uff0c\u9069\u5207\u306a\u51e6\u7f6e\u3092\u884c\u3063\u3066\u6442\u53d6\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\uff082\uff09\u306b\u95a2\u3057\u3066\u306e\u7c21\u6613\u5316\u306f\u73fe\u6bb5\u968e\u3067\u306f\u3053\u3053\u307e\u3067\u3067\u3059\u3002<\/p>\n

\n\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d\uff0d<\/p>\n

\u3000\u3000\u3000\u3000\u3000\u3000\u4ee5\u4e0a\u306e\u85e4\u539fDr.\u306e\u30b3\u30e1\u30f3\u30c8\u304b\u3089\u304a\u5bff\u53f8\u306f \u300c\u306a\u307e\u3082\u306e\u300d \u3068\u3044\u3046\u610f\u5473\u3067\u306f\uff082\uff09\u306e\u53ef\u80fd\u6027\u3068\u3057\u3066\u907f\u3051\u308b\u5fc5\u8981\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u3002\u5bff\u53f8\u30cd\u30bf\u306b\u3088\u3063\u3066\u306f\uff081\uff09\u3082\u3042\u308a\u5f97\u308b\u3067\u3057\u3087\u3046\u3002\u304a\u5e97\u306e\u885b\u751f\u72b6\u614b\u3084\u5bff\u53f8\u8077\u4eba\u306e\u624b\u306e\u72b6\u6cc1\u306b\u3082\u3088\u308a\u307e\u3059\u304c\uff0c\u4f5c\u308b\u904e\u7a0b\u306b\u304a\u3044\u3066\u306f\uff081\uff09\u304b\uff082\uff09\u304b\u306f\u5225\u3068\u3057\u3066\u591a\u5c11\u306e\u83cc\u304c\u6df7\u5165\u3059\u308b\u53ef\u80fd\u6027\u3082\u51fa\u3066\u304d\u307e\u3059\u3002\u305d\u306e\u4ed6\u306b\uff0c\u907f\u3051\u305f\u65b9\u304c\u826f\u3044\u3082\u306e\u306fCDC\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3084\uff0c\u65e5\u672c\u9020\u8840\u7d30\u80de\u79fb\u690d\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u3082\u8a18\u8f09\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u7d0d\u8c46\u3084\u30c1-\u30ba\u3067\u3059\u3002\u888b\u83d3\u5b50\u3084\u6e05\u6f54\u306b\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u98df\u54c1\u306f\u3082\u3061\u308d\u3093\u98df\u3079\u3066\u3082\u826f\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3000\u3000\u3000 \u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000 <\/p>\n

\u3069\u3093\u306a\u7269\u3092\u98df\u3079\u3066\u3044\u308b\uff1f
\n\u3000\u5199\u771f\u306f\u666e\u901a\u306e\u98df\u4e8b\u3068\u79fb\u690d\u4f8b\u3092\u53d7\u3051\u3066\u3044\u308b\u65b9\uff0d\u3044\u308f\u3086\u308b\u751f\u7981\uff0d\u306e\u98df\u4e8b\u3067\u3059\u3002\u4e00\u898b\uff0c\u666e\u901a\u306e\u98df\u4e8b\u306b\u307f\u3048\u308b\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f\u9055\u3044\u306f\u679c\u7269\u306b\u3064\u3044\u3066\u8a00\u3048\u3070\uff0c\u5199\u771f\u5de6\u306f\u76ae\u306e\u3064\u3044\u305f\u679c\u7269\u304c\u3064\u3044\u3066\u3044\u307e\u3059\u3002\u79fb\u690d\u5f8c\u306e\u597d\u4e2d\u7403\u6e1b\u5c11\u6642\u306e\u98df\u4e8b\u3067\u3059\u3002\u53f3\u306f\u666e\u901a\u98df\u3067\u3059\u3002\u3068\u3053\u308d\u304c\u3053\u308c\u304c\u610f\u5916\u3068\u4e0d\u8a55\u3067\u3059\u3002\u3042\u3063\u3055\u308a\u3057\u305f\u5473\u4ed8\u3051\u3060\u304b\u3089\u3067\u3059\u3002<\/p>\n

\u3069\u3093\u306a\u7269\u3092\u98df\u3079\u305f\u3044\uff1f
\n\u3000\u5171\u901a\u3057\u3066\u5316\u5b66\u7642\u6cd5\u4e2d\u306e\u7686\u3055\u3093\u304b\u3089\u8981\u671b\u3055\u308c\u308b\u306e\u306f\uff0c\u3057\u3063\u304b\u308a\u3057\u305f\u5473\u4ed8\u3051\u306e\u3082\u306e\u3068\u3044\u3046\u5e0c\u671b\u3067\u3059\u3002\u98df\u3079\u305f\u3044\u3082\u306e\u30d9\u30b9\u30c8\uff13\u306f\u30ab\u30ec\u30fc\uff0c\u30e9\u30fc\u30e1\u30f3\uff0c\u713c\u305d\u3070\u3067\u3059\u3002\u305d\u306e\u4ed6\u306b\u306f\u30ad\u30e0\u30c1\u3082\u3042\u308a\u307e\u3059\u3002\u306f\u3063\u304d\u308a\u3057\u305f\u5473\u4ed8\u3051\u306b\u5e0c\u671b\u304c\u96c6\u4e2d\u3057\u307e\u3059\u3002\u30ab\u30c3\u30d7\u30cc\u30fc\u30c9\u30eb\u3082\u4eba\u6c17\u3067\u3059\u3002<\/p>\n

\u3053\u3093\u306a\u98df\u4e8b\u304c\u3042\u308c\u3070\uff1f
\n\u3000\u5165\u9662\u4e2d\u306e\u60a3\u8005\u3055\u3093\u306e\u98df\u4e8b\u3078\u306e\u95a2\u5fc3\u306f\u9ad8\u3044\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u75c5\u68df\u5185\u3067\u98df\u4e8b\u304c\u9078\u629e\u30e1\u30cb\u30e5\u30fc\u306b\u306a\u3063\u3066\u3044\u3066\uff0c\u5358\u54c1\u3092\u6ce8\u6587\u3057\u3066\u98df\u3079\u308b\u3053\u3068\u304c\u51fa\u6765\u3066\uff0c\u5c11\u3057\u305a\u3064\u54c1\u6570\u3092\u3068\u308c\u308b\u3068\uff13\u5ea6\u306e\u98df\u4e8b\u304c\u697d\u3057\u3044\u3082\u306e\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u305d\u3093\u306a\u306b\u591a\u304f\u306e\u91cf\u306f\u3044\u3089\u306a\u3044\u306e\u3067\u3059\u304b\u3089\u3002<\/p>\n

\n\u6587\u3000\u3000\u732e
\n\uff11\uff0eKu Yi-Min et al. Effects of grapefruits juice on the pharmacokinetics of microemulsion cyclosporine and its metabolite in healthy volunteers: Does the formulation difference matter? J Clin Pharmacol 1998; 38: 959-965.<\/p>\n

http:\/\/www.minc.ne.jp\/kasii\/501-5.htm<\/p>\n

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