{"id":226,"date":"2009-07-27T20:47:58","date_gmt":"2009-07-27T11:47:58","guid":{"rendered":"http:\/\/haruko.km2m.net\/2009\/07\/27\/%e9%9d%9e%e3%83%9b%e3%82%b8%e3%82%ad%e3%83%b3%e3%83%aa%e3%83%b3%e3%83%91%e8%85%ab%e5%af%be%e8%b1%a1%e3%81%ae%e3%83%95%e3%82%a7%e3%83%bc%e3%82%ba3%e3%80%81%e3%82%84%e3%81%a3%e3%81%b1%e3%82%8a%e3%83%94\/"},"modified":"2009-07-27T20:47:58","modified_gmt":"2009-07-27T11:47:58","slug":"%e9%9d%9e%e3%83%9b%e3%82%b8%e3%82%ad%e3%83%b3%e3%83%aa%e3%83%b3%e3%83%91%e8%85%ab%e5%af%be%e8%b1%a1%e3%81%ae%e3%83%95%e3%82%a7%e3%83%bc%e3%82%ba3%e3%80%81%e3%82%84%e3%81%a3%e3%81%b1%e3%82%8a%e3%83%94","status":"publish","type":"post","link":"https:\/\/haruko.km2m.net\/?p=226","title":{"rendered":"\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u5bfe\u8c61\u306e\u30d5\u30a7\u30fc\u30ba3\u3001\u3084\u3063\u3071\u308a\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u304c\u6709\u52b9"},"content":{"rendered":"

\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u5bfe\u8c61\u306e\u30d5\u30a7\u30fc\u30ba3\u3001\u3084\u3063\u3071\u308a\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u304c\u6709\u52b9<\/p>\n

2009. 6. 26<\/p>\n

\u3000\u7c73Cell Therapeutics\u793e\uff08CTI\u793e\uff09\u306f6\u670822\u65e5\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u306e\u81e8\u5e8a\u958b\u767a\u306b\u95a2\u3059\u308b\u6700\u65b0\u30c7\u30fc\u30bf\u3092\u516c\u8868\u3057\u305f\u3002\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u6539\u3081\u3066\u793a\u3055\u308c\u305f\u3002\u8a73\u7d30\u306f\u3001\u30ab\u30ca\u30c0Ottawa\u7dcf\u5408\u75c5\u9662\u306eRichard Van der Jagt\u6c0f\u3089\u304c\u3001\u74b0\u592a\u5e73\u6d0b\u30ea\u30f3\u30d1\u816b\u4f1a\u8b702009\u3067\u5831\u544a\u3057\u305f\u3002<\/p>\n

\u3000\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u306f\u3001\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u306e\u6297\u764c\u6d3b\u6027\u306f\u7dad\u6301\u3057\u306a\u304c\u3089\u3001\u5fc3\u81d3\u6bd2\u6027\u3092\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u8a2d\u8a08\u3055\u308c\u305f\u85ac\u5264\u3002CTI\u793e\u306f\u30d5\u30a7\u30fc\u30ba3 EXTEND\u8a66\u9a13\uff08PIX301\uff09\u3067\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u304c\u9054\u6210\u3055\u308c\u305f\u3053\u3068\u3092\u3059\u3067\u306b\u5831\u544a\u3057\u3066\u3044\u308b\u3002\u4eca\u56de\u306f\u3001\u3053\u306e\u8a66\u9a13\u306e\u8ffd\u8de1\u30c7\u30fc\u30bf\u3068\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u306e\u7d50\u679c\u304c\u516c\u8868\u3055\u308c\u305f\u3002<\/p>\n

\u3000\u5bfe\u8c61\u3068\u306a\u3063\u305f\u306e\u306f\u3001\u8907\u6570\u306e\u85ac\u5264\u3092\u4f75\u7528\u3059\u308b\u5316\u5b66\u7642\u6cd5\u3092\u4e8c\u901a\u308a\u4ee5\u4e0a\u53d7\u3051\u3066\u3044\u308b\u518d\u767a\u6027\u307e\u305f\u306f\u96e3\u6cbb\u6027\u306e\u60aa\u6027\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u306e\u60a3\u8005\u3067\u3001\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306f\u7dad\u6301\u3057\u3066\u3044\u308b140\u4eba\u3002\u7121\u4f5c\u70ba\u306b\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u306e\u5358\u5264\u6295\u4e0e\uff0870\u4eba\uff09\u3001\u307e\u305f\u306f\u3001\u3053\u306e\u7a2e\u306e\u60a3\u8005\u306b\u6a19\u6e96\u7684\u306b\u7528\u3044\u3089\u308c\u308b\u5316\u5b66\u7642\u6cd5\u85ac\u306e\u5358\u5264\u6295\u4e0e\uff0870\u4eba\uff09\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002<\/p>\n

\u3000\u5b8c\u5168\u5bdb\u89e3\uff08CR\uff09\u307e\u305f\u306f\u4e0d\u78ba\u5b9a\u5b8c\u5168\u5bdb\u89e3\uff08CRu\uff09\u3092\u9054\u6210\u3057\u305f\u60a3\u8005\u306e\u5272\u5408\u306f\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u7fa4\u3067\u306f70\u4eba\u4e2d17\u4eba\uff0824\uff05\uff09\u3001\u6a19\u6e96\u6cbb\u7642\u7fa4\u3067\u306f70\u4eba\u4e2d5\u4eba\uff087\uff05\uff09\u3068\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u7fa4\u3067\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\uff08p=0.009\uff09\u3002<\/p>\n

\u3000\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u7fa4\u306e\u5168\u594f\u52b9\u7387\uff08\u6cbb\u7642\u7fa4\u306b\u5360\u3081\u308bCR\u3001CRu\u3001\u90e8\u5206\u5bdb\u89e3\u306e\u3044\u305a\u308c\u304b\u3092\u9054\u6210\u3057\u305f\u60a3\u8005\u306e\u5272\u5408\u300170\u4eba\u4e2d28\u4eba\u306740\uff05\uff09\u306f\u3001\u5bfe\u7167\u7fa4\u306e\u305d\u308c\uff0870\u4eba\u4e2d10\u4eba\u300114.3\uff05\uff09\u3092\u6709\u610f\u306b\u4e0a\u56de\u3063\u305f\uff08p=0.001\uff09\u3002<\/p>\n

\u3000\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u3042\u3089\u304b\u3058\u3081\u8a2d\u5b9a\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3044\u3066\u3001\u594f\u52b9\u7387\u306f\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u7fa4\u306e\u307b\u3046\u304c\u9ad8\u304b\u3063\u305f\u300265\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u3067\u306f\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u7fa4\u306eCR\u304bCRu\u306e\u4eba\u306e\u5272\u5408\uff08CR\/CRu\uff09\u306f26.1\uff05\uff0823\u4eba\u4e2d6\u4eba\uff09\u3001\u5ba2\u89b3\u7684\u594f\u529f\u7387\uff08ORR\uff09\u306f47.8\uff05\uff0823\u4eba\u4e2d11\u4eba\uff09\u3001\u5bfe\u7167\u7fa4\u3067\u306fCR\u3084Cru\u306e\u9054\u6210\u8005\u306f\u306a\u304f\u3001ORR\u306f5.6\uff05\uff0818\u4eba\u4e2d1\u4eba\uff09\u3060\u3063\u305f\u3002<\/p>\n

\u3000\u76f4\u8fd1\u306e\u6cbb\u7642\u3092\u53d7\u3051\u3066\u304b\u3089\u518d\u767a\u3092\u898b\u305f\u60a3\u8005\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u7fa4\u306eCR\/CRu\u306f28.8\uff05\uff0828\u4eba\u4e2d8\u4eba\uff09\u3001ORR\u306f50\uff05\uff0828\u4eba\u4e2d14\u4eba\uff09\u3002\u5bfe\u7167\u7fa4\u306f\u305d\u308c\u305e\u308c6.7\uff05\uff0830\u4eba\u4e2d2\u4eba\uff09\u306816.7\uff05\uff0830\u4eba\u4e2d5\u4eba\uff09\u3002<\/p>\n

\u3000\u5148\u306e\u6cbb\u7642\u306b\u53cd\u5fdc\u3057\u306a\u304b\u3063\u305f\u96e3\u6cbb\u6027\u306e\u60a3\u8005\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u7fa4\u306eCR\/CRu\u306f15\uff05\uff0840\u4eba\u4e2d6\u4eba\uff09\u3001ORR\u306f30.0\uff05\uff0840\u4eba\u4e2d12\u4eba\uff09\u3001\u5bfe\u7167\u7fa4\u3067\u306f\u305d\u308c\u305e\u308c5.0\uff05\uff0840\u4eba\u4e2d2\u4eba\uff09\u306812.5\uff05\uff0840\u4eba\u4e2d5\u4eba\uff09\u3002<\/p>\n

\u3000\u56fd\u969b\u4e88\u5f8c\u6307\u6570\uff08IPI\uff09\u304c2\u4ee5\u4e0a\u306e\u60a3\u8005\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u7fa4\u306eCR\/CRu\u306f18.0\uff05\uff0850\u4eba\u4e2d9\u4eba\uff09\u3001ORR\u306f32\uff05\uff0850\u4eba\u4e2d16\u4eba\uff09\u3001\u5bfe\u7167\u7fa4\u306f\u305d\u308c\u305e\u308c5.9\uff05\uff0851\u4eba\u4e2d3\u4eba\uff09\u306815.7\uff05\uff0851\u4eba\u4e2d8\u4eba\uff09\u3060\u3063\u305f\u3002<\/p>\n

\u3000\u3053\u306e\u8a66\u9a13\u306e\u8ffd\u8de1\u306f\u73fe\u5728\u3082\u9032\u884c\u4e2d\u3060\u3002<\/p>\n

\u3000\u74b0\u592a\u5e73\u6d0b\u30ea\u30f3\u30d1\u816b\u4f1a\u8b702009\u3067\u306f\u3001\u7121\u4f5c\u70ba\u5316\u30d5\u30a7\u30fc\u30ba3\uff08PIX302\uff09\u306e\u8ffd\u8de1\u7d50\u679c\u3068\u3001\u30d5\u30a7\u30fc\u30ba2\uff08AZA106\uff09\u8a66\u9a13\u306e\u7d50\u679c\u3082\u5831\u544a\u3055\u308c\u305f\u3002PIX302\u306f\u3001\u518d\u767a\u3057\u305f\u7de9\u6162\u6027\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3+\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3068\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u5358\u72ec\u306e\u6709\u52b9\u6027\u3092\u6bd4\u8f03\u3057\u305f\u8a66\u9a13\u3067\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u306e\u8ffd\u52a0\u306b\u3088\u308aCR\uff08\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u8ffd\u52a0\u7fa4\u304c35\uff05\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u5358\u5264\u7fa4\u304c11\uff05\uff09\u3001ORR\uff08\u540c75\uff05\u306833\uff05\uff09\u3001\u7121\u5897\u60aa\u671f\u9593\uff08\u540c13.2\u30ab\u6708\u30688.1\u30ab\u6708\uff09\u304c\u3059\u3079\u3066\u6539\u5584\u3057\u305f\u3002<\/p>\n

\u3000AZA106\u306f\u3001\u591a\u767a\u6027\u518d\u767a\u3092\u898b\u305f\u7de9\u6162\u6027\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u60a3\u8005\u306b\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3+\u30d5\u30eb\u30c0\u30e9\u30d3\u30f3+\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\uff08FPD-R\u30ec\u30b8\u30e1\u30f3\uff09\u3092\u6295\u4e0e\u3057\u305f\u8a66\u9a13\u3067\u3001\u9ad8\u3044CR\/CRu\uff0870\uff05\uff09\u3068ORR\uff0889\uff05\uff09\u304c\u898b\u3089\u308c\u305f\u3002\u307b\u307c\u5168\u54e1\u306b\u3001\u7b2c\u4e00\u9078\u629e\u85ac\u3068\u3057\u3066CHOP-R\uff08\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9\uff0b\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\uff0b\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\uff0b\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3\u3068\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3092\u7528\u3044\u308b\uff09\u304c\u7528\u3044\u3089\u308c\u3066\u3044\u305f\u3002<\/p>\n

\u3000CTI\u793e\u306f2009\u5e744\u6708\u3001\u7c73\u56fd\u3067\u3001\u518d\u767a\u6027\u307e\u305f\u306f\u96e3\u6cbb\u6027\u306e\u60aa\u6027\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u3092\u5bfe\u8c61\u3068\u3059\u308b\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u306e\u627f\u8a8d\u7533\u8acb\u306e\u6bb5\u968e\u7684\u63d0\u51fa\uff08rolling submission\uff09\u3092\u958b\u59cb\u3057\u3066\u3044\u308b\u3002<\/p>\n

\uff08\u5927\u897f \u6df3\u5b50=\u533b\u5b66\u30e9\u30a4\u30bf\u30fc\uff09<\/p>\n

\nhttp:\/\/medical.nikkeibp.co.jp\/leaf\/all\/search\/cancer\/news\/200906\/511330.html<\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u5bfe\u8c61\u306e\u30d5\u30a7\u30fc\u30ba3\u3001\u3084\u3063\u3071\u308a\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u304c\u6709\u52b9 2009. 6. 26 \u3000\u7c73Cell Therapeutics\u793e\uff08CTI\u793e\uff09\u306f6\u670822\u65e5\u3001\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u306e\u81e8\u5e8a\u958b\u767a\u306b\u95a2\u3059\u308b\u6700\u65b0\u30c7\u30fc\u30bf\u3092\u516c\u8868\u3057\u305f\u3002\u975e\u30db\u30b8\u30ad\u30f3 … <\/p>\n

“\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u5bfe\u8c61\u306e\u30d5\u30a7\u30fc\u30ba3\u3001\u3084\u3063\u3071\u308a\u30d4\u30af\u30b5\u30f3\u30c8\u30ed\u30f3\u304c\u6709\u52b9” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-226","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=226"}],"version-history":[{"count":0,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/226\/revisions"}],"wp:attachment":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}