{"id":23,"date":"2004-01-01T00:00:00","date_gmt":"2003-12-31T15:00:00","guid":{"rendered":"http:\/\/haruko.km2m.net\/2004\/01\/01\/%e6%82%aa%e6%80%a7%e3%83%aa%e3%83%b3%e3%83%91%e8%85%ab%e3%81%ae%e8%a8%ba%e6%96%ad%e3%81%a8%e6%b2%bb%e7%99%82-2004%e5%b9%b4\/"},"modified":"2004-01-01T00:00:00","modified_gmt":"2003-12-31T15:00:00","slug":"%e6%82%aa%e6%80%a7%e3%83%aa%e3%83%b3%e3%83%91%e8%85%ab%e3%81%ae%e8%a8%ba%e6%96%ad%e3%81%a8%e6%b2%bb%e7%99%82-2004%e5%b9%b4","status":"publish","type":"post","link":"https:\/\/haruko.km2m.net\/?p=23","title":{"rendered":"\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306e\u8a3a\u65ad\u3068\u6cbb\u7642 2004\u5e74"},"content":{"rendered":"

\u60aa\u6027\u30ea\u30f3\u30d1\u816b<\/p>\n

\u6982\u5ff5\uff1a
\n\u30ea\u30f3\u30d1\u7bc0\u306e\u69cb\u6210\u7d30\u80de\u306b\u7531\u6765\u3059\u308b\u9020\u8840\u5668\u60aa\u6027\u816b\u760d\u3067\u3042\u308b\u3002\u3000\u30ea\u30f3\u30d1\u7bc0\u816b\u8139\u306b\u3088\u308b\u5c40\u6240\u75c7\u72b6\u3068\u3001\u767a\u71b1\u3001\u4f53\u91cd\u6e1b\u5c11\u3001\u5bdd\u6c57\u3001\u76ae\u75b9\u306a\u3069\u306e\u5168\u8eab\u75c7\u72b6\u3092\u751f\u3058\u3046\u308b\u3002\u3000\u4e3b\u305f\u308b\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306f\u3001\u5927\u304d\u304f\u30db\u30b8\u30ad\u30f3\u75c5(Hodgkin disease)\u3068\u3001\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b(Non-Hodgkin lymphoma)\u306b\u5206\u985e\u3055\u308c\u308b\u3002\u3000 <\/p>\n

\n\u691c\u67fb\uff1a
\n\u554f\u8a3a\u3001\u8eab\u4f53\u6240\u898b\u304b\u3089\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u304c\u7591\u308f\u308c\u305f\u5834\u5408\u3001\u8a3a\u65ad\u306e\u305f\u3081\u30ea\u30f3\u30d1\u7bc0\u306a\u3069\u306e\u75c5\u5909\u7d44\u7e54\u3092\u751f\u691c\u3057\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u3092\u3064\u3051\u308b\u5fc5\u8981\u304c\u3042\u308b\uff08\u751f\u691c\u6a19\u672c\u51e6\u7406\u306e\u5177\u4f53\u7684\u306a\u65b9\u6cd5\u306b\u3064\u3044\u3066\u306f\u30017.2\u3092\u53c2\u7167\uff09\u3002\u3000\u751f\u691c\u90e8\u4f4d\u306b\u5fdc\u3058\u3066\u3001\u5f53\u8a72\u79d1\uff08\u8033\u9f3b\u79d1\u3001\u5f62\u6210\u5916\u79d1\u3001\u5916\u79d1\u306a\u3069\uff09\u306b\u4f9d\u983c\u3002<\/p>\n

\n\u8840\u7b97\uff1a\u3000\u8d64\u8840\u7403\u3001Hb\u3001\u767d\u8840\u7403\u3001\u5206\u753b\u3001\u8840\u5c0f\u677f\u3002\u3000\u8840\u6db2\u751f\u5316\u5b66\u3001\u514d\u75ab\u691c\u67fb\uff1a\u3000\u7dcf\u86cb\u767d\u3001\u86cb\u767d\u5206\u753b\u3001ALP\u3001LDH\u3001ALP\u3001\u03b3-GTP\u3001CRP\u3001\u8d64\u6c88\u3001HTLV-1\u3001HIV\u3001EBV\u3001\u81ea\u5df1\u514d\u75ab\u73fe\u8c61\u306e\u5b58\u5728\u304c\u7591\u308f\u308c\u308b\u3068\u304d\u306f\u3001\u81ea\u5df1\u6297\u4f53\u306a\u3069\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u6e96\u3058\u305f\u691c\u67fb\u3092\u884c\u3044\u691c\u7d22\u3059\u308b\u3002\u3000\u03b22\u30df\u30af\u30ed\u30b0\u30ed\u30d6\u30ea\u30f3\u3001\u30c1\u30df\u30b8\u30f3\u30ad\u30ca\u30fc\u30bc\u3001\u53ef\u6eb6\u6027IL-2\u53d7\u5bb9\u4f53\u306a\u3069\u3092\u30c1\u30a7\u30c3\u30af\u3059\u308b\u3002\u3000<\/p>\n

\u9aa8\u9ac4\uff1a\u3000\u9aa8\u9ac4\u3078\u306e\u816b\u760d\u7d30\u80de\u6d78\u6f64\u306e\u30c1\u30a7\u30c3\u30af\u306e\u305f\u3081\u65bd\u884c\u3059\u308b\u3002\u3000\u751f\u691c\u3092\u542b\u3081\u3001\u4e21\u5074\u306e\u8178\u9aa8\u304b\u3089\u65bd\u884c\u3059\u308b\u306e\u304c\u671b\u307e\u3057\u3044\u3002\u3000\u5168\u8eab\u75c5\u5909\u8a55\u4fa1\uff1a\u3000\u5168\u8eabCT\u3001\u30ac\u30ea\u30a6\u30e0\u30b7\u30f3\u30c1\u3001PET\u3092\u884c\u3046\u3002\u3000\u307e\u305f\u3001\u8033\u9f3b\u79d1\u9818\u57df\u306e\u30ea\u30f3\u30d1\u7bc0\u306b\u3064\u3044\u3066\u3082\u75c5\u5909\u306e\u5b58\u5728\u304c\u7591\u308f\u308c\u305f\u5834\u5408\u3001\u8033\u9f3b\u79d1\u3067\u8a55\u4fa1\u3057\u3066\u3044\u305f\u3060\u304f\u3002 <\/p>\n

\n\u8a3a\u65ad\u57fa\u6e96\uff1a
\n\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u3067\u884c\u3046\u3002\u3000\u57fa\u672c\u7684\u306b\u306fWHO\u5206\u985e\u3092\u4f7f\u7528\u3002 <\/p>\n

\n\u75c5\u671f\u5206\u985e\uff1a
\n\u57fa\u672c\u7684\u306b\u306fCostswolds\u306e\u5206\u985e\u3092\u4f7f\u7528\u3002\u3000 <\/p>\n

\n\u6cbb\u7642\uff1a
\n\u30ea\u30f3\u30d1\u816b\u306e\u6cbb\u7642\u306f\u3001\u7d44\u7e54\u8a3a\u65ad\u3001\u75c5\u671f\u306a\u3069\u306b\u3088\u308a\u591a\u5f69\u3067\u3042\u308b\u3002 <\/p>\n

\u30db\u30b8\u30ad\u30f3\u75c5\uff1a \u65e9\u671f\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b(IA\u3001IIA\u3001\u5de8\u5927\u75c5\u5909\u306a\u3057)\u306b\u5bfe\u3057\u3066\u306fABVD\uff14\u30b3\u30fc\u30b9\uff0b\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u65bd\u884c\u3059\u308b\u3002\u3000\u521d\u767a\u9032\u884c\u671f(IB\u3001IIB\u3001III\u3001IV\u671f)\u306b\u5bfe\u3057\u3066\u306fABVD\u7642\u6cd5\uff16\uff5e\uff18\u30b3\u30fc\u30b9\u3092\u6a19\u6e96\u3068\u3059\u308b\u3002\u3000\u6b8b\u5b58\u75c5\u5909\u3001\u6cbb\u7642\u524d\u306e\u5de8\u5927\u75c5\u5909\u306b\u5bfe\u3057\u3066\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u65bd\u884c\u3059\u308b\u3002 <\/p>\n

\n\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\uff1a
\n\u4f4e\u60aa\u6027\u5ea6\u30ea\u30f3\u30d1\u816b\uff1b\uff08\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3001\u30ea\u30f3\u30d1\u5f62\u8cea\u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3001\u6ffe\u80de\u8fba\u7e01\u5e2fB\u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3001small lymphocytic lymphoma\uff09\uff08\u3053\u3053\u3067\u306f\u3001\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u306e\u6cbb\u7642\u3092\u4e2d\u5fc3\u306b\u8a18\u8f09\uff09 <\/p>\n

\nAnn Arbor I, II\u671f\uff1a\u3000involved field radiotherapy\u306b\u3088\u308ameidan survival 10\u5e74\u304c\u671f\u5f85\u3067\u304d\u308b\u3002\u3000bulky mass, B\u75c7\u72b6\u3001LDH \u4e0a\u6607\u306a\u3069\u306e\u4e88\u5f8c\u4e0d\u826f\u56e0\u5b50\u304c\u3042\u308b\u5834\u5408\u3067\u306fStage III-IV\u3068\u540c\u69d8\u306e\u6cbb\u7642\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002 <\/p>\n

\nAnn Arbor III-IV\u671f\uff1a\u3000\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u306f\u8a3a\u65ad\u6642\u300180\uff05\u306fstage III-IV\u3067\u3042\u308b\u3002\u3000\u5316\u5b66\u7642\u6cd5\u306e\u307f\u3067\u306e\u6cbb\u7652\u306f\u56f0\u96e3\u3067\u3042\u308a\u3001\u7121\u75c7\u72b6\u3001\u9ad8\u9f62\u3001\u5408\u4f75\u75c7\u3042\u308a\u3001\u81ea\u7136\u9000\u7e2e\u50be\u5411\u3092\u8a8d\u3081\u305f\u3053\u3068\u304c\u3042\u308b\u306a\u3069\u306e\u4e00\u5b9a\u306e\u57fa\u6e96\u3092\u6e80\u305f\u3057\u305f\u75c7\u4f8b\u3092watchful waiting\u3067\u7d4c\u904e\u3092\u898b\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u4e0a\u8a18\u4ee5\u5916\u3067\u306f\u3001CD20\u967d\u6027\u306e\u3082\u306e\u306b\u3064\u3044\u3066\u306f\u6297CD20\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53(\u30ea\u30c4\u30ad\u30b7\u30de\u30d6) \u3068\u5316\u5b66\u7642\u6cd5\u3068\u306e\u4f75\u7528\uff08CHOP\u7642\u6cd5\u3001COP\u7642\u6cd5\u3001EP\u7642\u6cd5\u306a\u3069\uff09\u3067\u6cbb\u7642\u3092\u884c\u3046\u3002\u3000<\/p>\n

\u6cbb\u7642\u521d\u671f\u306b\u816b\u760d\u7dcf\u91cf\u304c\u8457\u3057\u304f\u591a\u304f\u3001rituximab\u3067infusion reaction\u3092\u751f\u3058\u308b\u5371\u967a\u304c\u9ad8\u3044\u5834\u5408\u306b\u306f\u30011-2\u30b3\u30fc\u30b9\u76ee\u3092CHOP\u7642\u6cd5\u3067\u65bd\u884c\u3057\u3001\u305d\u306e\u5f8cR-CHOP\u7642\u6cd5\u3092\u65bd\u884c\u3002\u3000<\/p>\n

\u307e\u305f\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3092\u7528\u3044\u305fin-vivo purged ASCT(\u81ea\u5bb6\u9020\u8840\u7d30\u80de\u79fb\u690d)\u306a\u3069\u3082\u691c\u8a0e\u3059\u308b\u3002\u3000<\/p>\n

\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u5316\u5b66\u7642\u6cd5\u3001\u6297\u4f53\u7642\u6cd5\u3067\u3082\u591a\u304f\u306e\u60a3\u8005\u69d8\u306f\u3001\u6cbb\u7652\u56f0\u96e3\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u3000<\/p>\n

\u552f\u4e00\u3001\u6cbb\u7652\u304c\u898b\u8fbc\u307e\u308c\u308b\u6cbb\u7642\u3068\u3057\u3066\u540c\u7a2e\u79fb\u690d\u304c\u3042\u308b\u304c\u3001\u9ad8\u3044\u6cbb\u7642\u95a2\u9023\u6bd2\u6027\u3092\u4f34\u3044\u3001\u82e5\u304f\u3001\u5168\u8eab\u72b6\u614b\u304c\u826f\u3044\u75c7\u4f8b\u3084\u3001\u5144\u5f1f\u9593\u3067HLA\u304c\u4e00\u81f4\u3057\u3066\u3044\u308b\u75c7\u4f8b\u306a\u3069\u304c\u9069\u5fdc\u3068\u306a\u308b\u3002\u307e\u305f\u3001<\/p>\n

\u8fd1\u5e74\u3001\u9aa8\u9ac4\u975e\u7834\u58ca\u7684\u9020\u8840\u7d30\u80de\u79fb\u690d(\u30df\u30cb\u79fb\u690d)\u306b\u3088\u308a\u3001\u6cbb\u7642\u95a2\u9023\u6bd2\u6027\u3092\u8efd\u6e1b\u3059\u308b\u8a66\u307f\u304c\u3042\u308a\u3001\u6cbb\u7642\u306e\u9078\u629e\u80a2\u306e\u3072\u3068\u3064\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u3000\u5f53\u79d1\u3067\u306f\u3001\u4ed6\u306e\u6cbb\u7642\u306b\u3088\u3063\u3066\u3082\u96e3\u6cbb\u3067\u6cbb\u7642\u56f0\u96e3\u306a\u60a3\u8005\u69d8\u3092\u5bfe\u8c61\u3068\u3057\u3066\u30df\u30cb\u79fb\u690d\u3092\u65bd\u884c\u3059\u308b\u81e8\u5e8a\u7814\u7a76\u3092\u884c\u3046\u4e88\u5b9a\u3067\u3042\u308b\u3002 <\/p>\n

\n***\u30de\u30f3\u30c8\u30eb\u7d30\u80de\u30ea\u30f3\u30d1\u816b(MCL)
\n\u3000MCL\u306fmedian surivival\u304c3\uff5e5\u5e74\u306emost incurable lymphoma\u3067\u3042\u308b\u3002Working Formulation\u3067\u306f\u4f4e\u60aa\u6027\u5ea6\u30ea\u30f3\u30d1\u816b\u306b\u5206\u985e\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u4ed6\u306eindolent lymphoma\u3068\u6bd4\u8f03\u3057\u3066\u660e\u3089\u304b\u306b\u4e88\u5f8c\u4e0d\u826f\u3067\u3042\u308a\u3001CHOP\u7642\u6cd5\u306b\u5bfe\u3057\u3066\u3082\u96e3\u53cd\u5fdc\u3067\u3042\u308b\u3002\uff16\uff15\u6b73\u4ee5\u4e0b\u306e\u75c7\u4f8b\u306b\u5bfe\u3057\u3066\u306f\u3001Khouri et al.\u304c\u5831\u544a\u3057\u305fHyper-CVAD+HD-MTX\u7642\u6cd5\uff08J Clin Oncol 1998; 16: 3803\uff09\u306b\u6e96\u3058\u3066\u3001\u81ea\u5bb6\u672b\u68a2\u8840\u5e79\u7d30\u80de\u79fb\u690d\u3092\u4f75\u7528\u3057\u305f\u5f37\u529b\u306a\u591a\u5264\u4f75\u7528\u5316\u5b66\u7642\u6cd5\u306b\u3088\u3063\u3066\u6cbb\u7642\u3057\u3066\u3044\u308b\u3002\u3000\u4e00\u65b9\u3001\u81ea\u5bb6\u79fb\u690d\u306e\u9069\u5fdc\u304c\u306a\u3044\u9ad8\u9f62\u8005\u306a\u3069\u306b\u306fR-CHOP\u306a\u3069\u306e\u5316\u5b66\u7642\u6cd5\u3092\u65bd\u884c\u3059\u308b\u3002 <\/p>\n

\u4e2d\u60aa\u6027\u5ea6\u30ea\u30f3\u30d1\u816b\uff1b
\n\u9650\u5c40\u671f\uff08\u75c5\u671fI\u3001\u75c5\u671fIIA\u306e\u3046\u3061\u75c5\u5909\u90e8\u304c\u4e00\u7167\u5c04\u91ce\u306b\u5165\u308b\u3082\u306e\u3002\u3000\u305f\u3060\u3057\u3001\uff11\uff10cm\u4ee5\u4e0a\u306ebulky mass\u3092\u6709\u3059\u308b\u3082\u306e\u306f\u9664\u5916\u3059\u308b\u3002\uff09\uff1a
\n\u3000\u5316\u5b66\u7642\u6cd5\u3068\u5c40\u6240\u653e\u5c04\u7dda\u7642\u6cd5\u306e\u4f75\u7528\u7642\u6cd5\u3092\u6a19\u6e96\u6cbb\u7642\u3068\u3059\u308b\u3002\u3000CHOP\u7642\u6cd5 (21\u65e5) \u3092\uff13\u30b3\u30fc\u30b9\u65bd\u884c\u5f8c\u3001\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308b\u3002\u7167\u5c04\u91cf\u306f\u539f\u5247\u3067\uff11\u65e5\u7dda\u91cf\u304c1.8Gy\uff5e2.0Gy\u3067\u3001\u7dcf\u7dda\u91cf\u306f40\uff5e55Gy\u3067\u3042\u308b\u3002 <\/p>\n

\u9032\u884c\u671f\uff08\u9650\u5c40\u671f\u306b\u5206\u985e\u3055\u308c\u306a\u3044\u3082\u306e\uff09\uff1a
\n\u30001993\u5e74\u306b\u767a\u8868\u3055\u308c\u305fInternational prognosis index(IPI)\u306b\u3088\u308b\u5c64\u5225\u5316\u304c\u3001\u5b8c\u5168
\n\u5bdb\u89e3\u7387\u3068\u751f\u5b58\u7387\u3092\u826f\u304f\u4e88\u6e2c\u51fa\u6765\u3001risk adjusted therapy\u304c\u6a19\u6e96\u6cbb\u7642\u6cd5\u3068\u306a\u3063\u3066\u3044\u308b\u3002 <\/p>\n

\nIPI\u3000Low\/Low Intermediate
\nCHOP\u7642\u6cd5\uff16\uff5e\uff18\u30b3\u30fc\u30b9\u304c\u6a19\u6e96\u7684\u6cbb\u7642\u6cd5\u3067\u3042\u3063\u305f\u304c\u3001CD20\u967d\u6027\u306e\u3082\u306e\u306b\u5bfe\u3057\u3066\u306frituximab\u3092\u4f75\u7528\u3059\u308bR-CHOP\u7642\u6cd5\u3092\u6a19\u6e96\u6cbb\u7642\u3068\u3057\u3066\u3044\u308b\u3002 <\/p>\n

IPI\u3000High intermediate\/High
\nHI\/H\u7fa4\u306b\u5bfe\u3059\u308bCHOP\u7642\u6cd5\u306e\u52b9\u679c\u306f\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u6a19\u6e96\u6cbb\u7642\u306f\u672a\u78ba\u5b9a\u3067\u3042\u308b\u3002\u3000\u82e5\u304f\u3001\u5168\u8eab\u72b6\u614b\u306e\u826f\u597d\u306a\u3082\u306e\u306b\u3064\u3044\u3066\u306f\u3001first line\u306e\u6cbb\u7642\u3068\u3057\u3066\u3001\u81ea\u5bb6\u9020\u8840\u7d30\u80de\u79fb\u690d\u3092\u8003\u616e\u3059\u308b\u3002\u3000\u79fb\u690d\u524d\u306e\u5316\u5b66\u7642\u6cd5\u306f\u3001\u901a\u5e38\u306eCHOP\u7642\u6cd5\u30926-8\u30b3\u30fc\u30b9\u65bd\u884c\u5f8c\u304a\u3053\u306a\u3046regimen\u3084high-dose\u306e\u5316\u5b66\u7642\u6cd5\u3092\u77ed\u671f\u9593\u306b\u65bd\u884c\u3057\u305f\u5f8c\u306b\u884c\u3046regimen\u306a\u3069\u304c\u3042\u308b\u3002\u3000\u307e\u305f\u3001\u816b\u760d\u7d30\u80de\u306bCD20\u967d\u6027\u304c\u5834\u5408\u306f\u3001R-CHOP\u3092\u884c\u3046\u3002 <\/p>\n

\n\u9ad8\u60aa\u6027\u5ea6\u30ea\u30f3\u30d1\u816b\uff1b
\n\u30d0\u30fc\u30ad\u30c3\u30c8\u30ea\u30f3\u30d1\u816b\u30fb\u30d0\u30fc\u30ad\u30c3\u30c8\u69d8\u30ea\u30f3\u30d1\u816b\uff1b \u5316\u5b66\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u77ed\u671f\u96c6\u4e2d\u578b\u306e\u5316\u5b66\u7642\u6cd5\u3067\u6cbb\u7652\u304c\u671f\u5f85\u3067\u304d\u308b\u3002\u73fe\u5728\u3001Magrath\u3089\u304c\u5831\u544a\u3057\u305fCODOX-M\/IVAC\u7642\u6cd5(J Clin Oncol 14: 925-934, 1996)\u3092\u65bd\u884c\u3057\u3066\u3044\u308b\u3002 <\/p>\n

\n\u30ea\u30f3\u30d1\u82bd\u7403\u6027\u30ea\u30f3\u30d1\u816b\uff1b \u65e5\u672c\u3067\u306f\u307e\u308c\u306a\u30ea\u30f3\u30d1\u816b\u3067\u307e\u3068\u307e\u3063\u305f\u6cbb\u7642\u6210\u7e3e\u304c\u306a\u3044\u304c\u3001\u73fe\u5728\u306fALL\u306b\u5bfe\u3057\u3066\u65bd\u884c\u3055\u308c\u308b\u3088\u3046\u306a\u6cbb\u7642\u5f37\u5ea6\u3092\u9ad8\u3081\u305f\u591a\u5264\u4f75\u7528\u5316\u5b66\u7642\u6cd5\u306b\u4e2d\u67a2\u795e\u7d4c\u4e88\u9632\u3092\u4f75\u7528\u3059\u308b\u6cbb\u7642\u6cd5\u3092\u65bd\u884c\u3057\u3066\u3044\u308b\u3002 <\/p>\n

\n*** \u30d0\u30fc\u30ad\u30c3\u30c8\u30ea\u30f3\u30d1\u816b\u30fb\u30d0\u30fc\u30ad\u30c3\u30c8\u69d8\u30ea\u30f3\u30d1\u816b\u3001\u30ea\u30f3\u30d1\u82bd\u7403\u6027\u30ea\u30f3\u30d1\u816b\u306e\u3044\u305a\u308c\u3082\u3001\u5316\u5b66\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306f\u9ad8\u3044\u3082\u306e\u306e\u518d\u767a\u7387\u3082\u9ad8\u304f\u3001\u75c7\u4f8b\u306b\u3088\u308a\u3001\u540c\u7a2e\u79fb\u690d\u3092\u8003\u616e\u3059\u308b\u3002 <\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u60aa\u6027\u30ea\u30f3\u30d1\u816b \u6982\u5ff5\uff1a \u30ea\u30f3\u30d1\u7bc0\u306e\u69cb\u6210\u7d30\u80de\u306b\u7531\u6765\u3059\u308b\u9020\u8840\u5668\u60aa\u6027\u816b\u760d\u3067\u3042\u308b\u3002\u3000\u30ea\u30f3\u30d1\u7bc0\u816b\u8139\u306b\u3088\u308b\u5c40\u6240\u75c7\u72b6\u3068\u3001\u767a\u71b1\u3001\u4f53\u91cd\u6e1b\u5c11\u3001\u5bdd\u6c57\u3001\u76ae\u75b9\u306a\u3069\u306e\u5168\u8eab\u75c7\u72b6\u3092\u751f\u3058\u3046\u308b\u3002\u3000\u4e3b\u305f\u308b\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306f\u3001\u5927\u304d\u304f\u30db\u30b8\u30ad\u30f3\u75c5(Hodgkin dis … <\/p>\n

“\u60aa\u6027\u30ea\u30f3\u30d1\u816b\u306e\u8a3a\u65ad\u3068\u6cbb\u7642 2004\u5e74” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-23","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23"}],"version-history":[{"count":0,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/23\/revisions"}],"wp:attachment":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}