\u30a8\u30d9\u30ed\u30ea\u30e0\u30b9\u306e\u96e3\u6cbb\u6027\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u3078\u306e\u52b9\u679c\u304c\u65e5\u672c\u4eba\u3067\u3082\u78ba\u8a8d
\n\u6a2a\u5c71 \u52c7\u751f\uff1d\u65e5\u7d4c\u30e1\u30c7\u30a3\u30ab\u30eb\u5225\u518a<\/p>\n
\u540d\u53e4\u5c4b\u7b2c\u4e8c\u8d64\u5341\u5b57\u75c5\u9662\u8840\u6db2\u30fb\u816b\u760d\u5185\u79d1\u90e8\u9577\u306e\u5c0f\u690b\u7f8e\u77e5\u5247\u6c0f<\/p>\n
\u3000\u65e5\u672c\u4eba\u306e\u518d\u767a\u307e\u305f\u306f\u96e3\u6cbb\u6027\u306e\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u3092\u5bfe\u8c61\u306b\u3057\u305f\u3001mTOR\u963b\u5bb3\u5264\u3067\u3042\u308b\u30a8\u30d9\u30ed\u30ea\u30e0\u30b9\u306e\u30d5\u30a7\u30fc\u30ba1\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002\u60a3\u8005\u306f\u3001\u6295\u4e0e\u306b\u4e00\u822c\u7684\u306b\u5341\u5206\u8010\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u6297\u816b\u760d\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u7d50\u679c\u306f12\u67085\u65e5\u304b\u30898\u65e5\u307e\u3067\u30cb\u30e5\u30fc\u30aa\u30fc\u30ea\u30f3\u30ba\u3067\u958b\u50ac\u3055\u308c\u308b\u7b2c51\u56de\u7c73\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH 2009\uff09\u3067\u3001\u540d\u53e4\u5c4b\u7b2c\u4e8c\u8d64\u5341\u5b57\u75c5\u9662\u8840\u6db2\u30fb\u816b\u760d\u5185\u79d1\u90e8\u9577\u306e\u5c0f\u690b\u7f8e\u77e5\u5247\u6c0f\uff08\u5199\u771f\uff09\u306b\u3088\u3063\u3066\u767a\u8868\u3055\u308c\u305f\u3002<\/p>\n
\u3000mTOR\u306f\u3001PI3K\/Akt\u60c5\u5831\u4f1d\u9054\u7d4c\u8def\u306e\u4e0b\u6d41\u306b\u5b58\u5728\u3059\u308b\u3002\u60aa\u6027\u306e\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u306e1\u7a2e\u3067\u3042\u308b\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b(DLBCL)\u3067\u306fAkt\u306e\u69cb\u6210\u7684\u306a\u6d3b\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3001\u751f\u5b58\u671f\u9593\u4e0d\u826f\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08FL\uff09\u306e\u7d30\u80de\u3084\u672a\u5206\u5316\u5927\u7d30\u80de\u578b\u30ea\u30f3\u30d1\u816b\uff08anaplastic large-cell lymphoma\uff09\u306e\u7d30\u80de\u306e\u4e00\u90e8\u3067mTOR\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u304c\u4ea2\u9032\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n
\u3000\u30d5\u30a7\u30fc\u30ba1\u8a66\u9a13\u306f\u30011\u65e5\u5f53\u305f\u308a5mg\u3082\u3057\u304f\u306f10mg\u306e\u30a8\u30d9\u30ed\u30ea\u30e0\u30b9\u309228\u65e5\u30921\u30b5\u30a4\u30af\u30eb\u3068\u3057\u3066\u3001\u75c5\u72b6\u304c\u9032\u884c\u3059\u308b\u304b\u3042\u308b\u3044\u306f\u8a31\u5bb9\u7bc4\u56f2\u3092\u8d85\u3048\u308b\u6bd2\u6027\u304c\u78ba\u8a8d\u3055\u308c\u308b\u306a\u3069\u3057\u8a66\u9a13\u304c\u4e2d\u6b62\u3055\u308c\u308b\u307e\u3067\u6295\u4e0e\u3055\u308c\u305f\u30025mg\u7fa4\u306b\u306f7\u4eba\uff08\u7537\u60274\u4eba\uff09\u304c\u767b\u9332\u3055\u308c\u3001\u5e74\u9f62\u4e2d\u592e\u5024\u306f65\u6b73\uff0847-82\uff09\u3060\u3063\u305f\u3002\u524d\u6cbb\u7642\u3068\u3057\u30666\u4eba\u304c\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u30014\u4eba\u304c\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306e\u6295\u4e0e\u3092\u53d7\u3051\u3066\u3044\u305f\u300210mg\u7fa4\u306b\u306f6\u4eba\uff08\u7537\u60274\u4eba\uff09\u304c\u767b\u9332\u3055\u308c\u3001\u5e74\u9f62\u4e2d\u592e\u5024\u306f59\u6b73\uff0847-74\uff09\u3060\u3063\u305f\u3002\u524d\u6cbb\u7642\u3068\u3057\u3066\u5168\u54e1\u304c\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u30015\u4eba\u304c\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3092\u6295\u4e0e\u3055\u308c\u3066\u3044\u305f\u3002<\/p>\n
\u3000\u6297\u816b\u760d\u52b9\u679c\u306f5mg\u6295\u4e0e\u7fa4\u3067\u306f\u3001DLBCL\u60a3\u80051\u4eba\u306714\u30ab\u6708\u4ee5\u4e0a\u306e\u5b8c\u5168\u594f\u52b9\uff08CR\uff09\u3001DLBCL\u60a3\u80051\u4eba\u306712\u30ab\u6708\u4ee5\u4e0a\u306e\u90e8\u5206\u594f\u52b9\uff08PR\uff09\u304c\u5f97\u3089\u308c\u3001FL\u60a3\u80051\u4eba\u304c\u5b89\u5b9a\u72b6\u614b\uff08SD\uff09\u3068\u306a\u3063\u305f\u3002\u594f\u52b9\u7387\u306f28.6\uff05\u3060\u3063\u305f\u3002\u6b8b\u308a\u306e4\u4eba\u306f\u75c5\u72b6\u9032\u884c\u3057\u305f\u304c\u3001\u305d\u306e\u3046\u30613\u4eba\u306fT\u7d30\u80de\u6027\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u3060\u3063\u305f\u3002<\/p>\n
\u300010mg\u6295\u4e0e\u7fa4\u3067\u306f\u3001FL\u60a3\u80051\u4eba\u306711\u30ab\u6708\u4ee5\u4e0a\u306e\u5b8c\u5168\u594f\u52b9\uff08CR\uff09\u3001FL\u60a3\u80051\u4eba\u30671.5\u30ab\u6708\u306e\u90e8\u5206\u594f\u52b9\uff08PR\uff09\u304c\u5f97\u3089\u308c\u3001FL\u60a3\u80052\u4eba\u3068\u30de\u30f3\u30c8\u30eb\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u60a3\u80051\u4eba\u3001ALCL\u60a3\u80051\u4eba\u304c\u5b89\u5b9a\u72b6\u614b\uff08SD\uff09\u3068\u306a\u3063\u305f\u3002\u594f\u52b9\u7387\u306f33.3\uff05\u3060\u3063\u305f\u3002<\/p>\n
\u3000\u30d5\u30a7\u30fc\u30ba1\u8a66\u9a13\u306e\u7d50\u679c\u3001\u3059\u3079\u3066\u306e\u60a3\u8005\u3067\u30a8\u30d9\u30ed\u30ea\u30e0\u30b9\u306b\u95a2\u9023\u3057\u305f\u526f\u4f5c\u7528\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u5168\u3066\u306e\u526f\u4f5c\u7528\u306f\u4e00\u904e\u6027\u3067\u53ef\u9006\u7684\u3060\u3063\u305f\u3002\u9593\u8cea\u6027\u80ba\u75be\u60a3\uff08\u30b0\u30ec\u30fc\u30c91\uff09\u304c1\u4eba\u306e\u60a3\u8005\u3067\u898b\u3089\u308c\u305f\u304c\u3001\u8ffd\u52a0\u6cbb\u7642\u306a\u304f\u30a8\u30d9\u30ed\u30ea\u30e0\u30b9\u306e\u4e2d\u65ad\u3067\u56de\u5fa9\u3057\u305f\u3002\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u306f\u307e\u308c\u3067\u3001\u307b\u3068\u3093\u3069\u306e\u3082\u306e\u304c\u30b0\u30ec\u30fc\u30c93\u3060\u3063\u305f\u3002\u591a\u304f\u898b\u3089\u308c\u305f\u526f\u4f5c\u7528\u306f\u8ca7\u8840\u3001\u767d\u8840\u7403\u6e1b\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u3001\u53e3\u5185\u708e\u3001AST\u4e0a\u6607\u3001ALT\u4e0a\u6607\u3060\u3063\u305f\u3002<\/p>\n
\u3000\u30b0\u30ec\u30fc\u30c93\/4\u306e\u526f\u4f5c\u7528\u306f\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u304c\u591a\u304b\u3063\u305f\u30025mg\u6295\u4e0e\u7fa4\u3067\u306f\u3001\u30b0\u30ec\u30fc\u30c93\u306e\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u3092\u8d77\u3053\u3057\u305f\u306e\u304c1\u4eba\u3001\u30b0\u30ec\u30fc\u30c94\u306e\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u3092\u8d77\u3053\u3057\u305f\u306e\u304c1\u4eba\u3060\u3063\u305f\u300210mg\u6295\u4e0e\u7fa4\u3067\u306f\u3001\u30b0\u30ec\u30fc\u30c93\u306e\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11\u3092\u8d77\u3053\u3057\u305f\u306e\u304c2\u4eba\u3067\u30b0\u30ec\u30fc\u30c94\u306e\u60a3\u8005\u306f\u3044\u306a\u304b\u3063\u305f\u3002<\/p>\n
\u3000\u5c0f\u690b\u6c0f\u306f\u300c\u96e3\u6cbb\u6027\u306e\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u306b\u5bfe\u3057\u3066\u5358\u5264\u30673\u5272\u305d\u3053\u305d\u3053\u306e\u52b9\u679c\u304c\u3042\u308a\u3001CR\u3082\u5f97\u3089\u308c\u305f\u306e\u306f\u8a55\u4fa1\u3067\u304d\u308b\u300d\u3068\u8a9e\u3063\u305f\u3002\u73fe\u5728\u3001\u30cf\u30a4\u30ea\u30b9\u30af\u306e\u521d\u767aDLBCL\u306eR-CHOP\u5c0e\u5165\u7642\u6cd5\u5f8c\u306e\u7dad\u6301\u7642\u6cd5\u3068\u3057\u3066\u6bce\u65e5\u30a8\u30d9\u30ed\u30ea\u30e0\u30b910mg\u3092\u6295\u4e0e\u3059\u308b\u56fd\u969b\u7684\u306a\u30d5\u30a7\u30fc\u30ba3\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u304a\u308a\u3001\u65e5\u672c\u3082\u53c2\u52a0\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3002<\/p>\n
\n\u8a73\u3057\u304f\u306f\u3001<\/p>\n
http:\/\/medical.nikkeibp.co.jp\/leaf\/all\/gakkai\/ash2009\/200912\/513403.html<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
\u52b9\u304d\u76ee\u306f\u307e\u3042\u307e\u3042\u3068\u8a00\u3046\u3068\u3053\u308d\u3067\u3059\u3002 \u65e5\u672c\u767a\u3068\u8a00\u3046\u306e\u304c\u30dd\u30a4\u30f3\u30c8\u3067\u3059\u306d\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-239","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=239"}],"version-history":[{"count":0,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/239\/revisions"}],"wp:attachment":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}