{"id":24,"date":"2004-01-01T00:00:00","date_gmt":"2003-12-31T15:00:00","guid":{"rendered":"http:\/\/haruko.km2m.net\/2004\/01\/01\/%e5%8e%9a%e7%94%9f%e5%8a%b4%e5%83%8d%e7%9c%81%e7%8f%ad%e7%a0%94%e7%a9%b6-%e3%83%9f%e3%83%8b%e7%a7%bb%e6%a4%8d%e3%83%97%e3%83%ad%e3%83%88%e3%82%b3%e3%83%bc%e3%83%ab\/"},"modified":"2004-01-01T00:00:00","modified_gmt":"2003-12-31T15:00:00","slug":"%e5%8e%9a%e7%94%9f%e5%8a%b4%e5%83%8d%e7%9c%81%e7%8f%ad%e7%a0%94%e7%a9%b6-%e3%83%9f%e3%83%8b%e7%a7%bb%e6%a4%8d%e3%83%97%e3%83%ad%e3%83%88%e3%82%b3%e3%83%bc%e3%83%ab","status":"publish","type":"post","link":"https:\/\/haruko.km2m.net\/?p=24","title":{"rendered":"\u539a\u751f\u52b4\u50cd\u7701\u73ed\u7814\u7a76 \u30df\u30cb\u79fb\u690d\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb"},"content":{"rendered":"

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\n\uff5e\u9aa8\u9ac4\u975e\u7834\u58ca\u7684\u524d\u51e6\u7f6e\u7642\u6cd5\u306e\u6709\u7528\u6027\u3001\u306a\u3089\u3073\u306b\u6025\u6027GVHD\u306e\u4e88\u9632\u65b9\u6cd5\u306b\u95a2\u3059\u308b\u691c\u8a0e\uff5e<\/p>\n

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\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000day \uff0d\uff18\u3000\uff0d\uff17\u3000\uff0d\uff16\u3000\uff0d\uff15\u3000\uff0d\uff14\u3000\uff0d\uff13\u3000\uff0d\uff12\u3000\uff0d\uff11\u3000\u3000\uff10
\n\u30ea\u30f3\u9178\u30d5\u30eb\u30c0\u30e9\u30d3\u30f3 30mg\/m2\/day \u2193\u3000\u3000\u2193\u3000\u3000\u2193\u3000\u3000\u2193\u3000\u3000\u2193\u3000\u3000\u2193
\n\u30d6\u30b9\u30eb\u30d5\u30a1\u30f3 \u3000\u3000\u3000\u30004mg\/kg\/day \u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u2193\u3000\u3000\u2193
\n\u5e79\u7d30\u80de\u79fb\u690d \u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000 \u2193<\/p>\n

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\u7dcf\u62ec\u8cac\u4efb\u533b\u5e2b: \u9ad8\u4e0a\u6d0b\u4e00 (\u56fd\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u4e2d\u592e\u75c5\u9662)
\n\u672c\u8a66\u9a13\u306b\u95a2\u308f\u308b\u696d\u52d9\u3092\u7d71\u62ec\u3059\u308b\u533b\u5e2b<\/p>\n

\u8a66\u9a13\u8abf\u6574\u533b\u5e2b: \u5cef\u77f3\u771f(\u56fd\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u4e2d\u592e\u75c5\u9662)
\n\u672c\u8a66\u9a13\u306b\u95a2\u308f\u308b\u696d\u52d9\u306e\u7dcf\u62ec\u7684\u306a\u8cac\u4efb\u533b\u5e2b<\/p>\n

\u8a66\u9a13\u8cac\u4efb\u533b\u5e2b\u30fb\u8a66\u9a13\u5206\u62c5\u533b\u5e2b\uff1a \u5404\u65bd\u8a2d\u3088\u308a\u4efb\u547d
\n\u53c2\u52a0\u5404\u65bd\u8a2d\u3067\u3001\u8a66\u9a13\u306b\u95a2\u308f\u308b\u696d\u52d9\u3092\u5206\u62c5\u3057\u3001\u904b\u55b6\u4e8b\u52d9\u5c40\u3068\u306e\u9023\u7d61\u3092\u62c5\u3046\u3002<\/p>\n

\u904b\u55b6\u4e8b\u52d9\u5c40\u8cac\u4efb\u8005: \u795e\u7530\u5584\u4f38 (\u6771\u4eac\u5927\u5b66\u7121\u83cc\u6cbb\u7642\u90e8)
\n\u904b\u55b6\u4e8b\u52d9\u5c40\u306e\u696d\u52d9\u306e\u8cac\u4efb\u533b\u5e2b<\/p>\n

\u304a\u554f\u3044\u5408\u308f\u305b\u306f\u6771\u4eac\u5927\u5b66\u7121\u83cc\u6cbb\u7642\u90e8\u3000\u795e\u7530\u5584\u4f38
\nTEL: 03-3815-5411\u5185\u7dda30672 FAX: 03-5804-6261 E-mail:
\n\u5b9b\u306b\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002 <\/p>\n

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\n\u76ee\u7684
\n\u672c\u7814\u7a76\u3067\u306f\u3001\u5f93\u6765\u306e\u524d\u51e6\u7f6e\u7642\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u6cbb\u7642\u95a2\u9023\u6bd2\u6027\u304c\u8efd\u3044\u9aa8\u9ac4\u975e\u7834\u58ca\u7684\u306a\u8853\u524d\u7642\u6cd5\u3092\u7528\u3044\u306650\u6b73\u4ee5\u4e0a70\u6b73\u672a\u6e80\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30df\u30cb\u79fb\u690d\u8853\u3092\u884c\u3044\u3001\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u672c\u6cbb\u7642\u6cd5\u306e\u6709\u7528\u6027\uff08\u5b89\u5168\u6027\u30fb\u6709\u52b9\u6027\uff09\u3092\u691c\u8a0e\u3059\u308b\u3002\u307e\u305fGVHD\u4e88\u9632\u3092\u672c\u7814\u7a76\u306e\u524d\u51e6\u7f6e\u3067\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u5358\u5264\u306b\u3088\u308b\u65b9\u6cd5\u3068\u3001\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3068\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306e\u4f75\u7528\u306b\u3088\u308b\u65b9\u6cd5\u306e2\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u308b\u3053\u3068\u306b\u3088\u308a\u6025\u6027GVHD\u306e\u4e88\u9632\u65b9\u6cd5\u306b\u95a2\u3059\u308b\u691c\u8a0e\u3092\u884c\u3046\u3002\u306a\u304a\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u9aa8\u9ac4\u975e\u7834\u58ca\u7684\u524d\u51e6\u7f6e\u7642\u6cd5\u3092\u7528\u3044\u305f\u540c\u7a2e\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u306e\u6709\u7528\u6027(\u5b89\u5168\u6027\u30fb\u6709\u52b9\u6027)\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5834\u5408\u306b\u306f\u3001\u4ed6\u306b\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u304c\u306a\u3044\u591a\u304f\u306e\u60a3\u8005\u3092\u6551\u6e08\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u524d\u51e6\u7f6e\u7642\u6cd5)\u306b\u7528\u3044\u305f\u85ac\u5264\u306e\u8f38\u5165\u8ca9\u58f2\u4f1a\u793e\u306b\u5bfe\u3057\u3066\u9069\u5fdc\u75c7\u8ffd\u52a0\u7533\u8acb\u3092\u884c\u3046\u3088\u3046\u306b\u8981\u8acb\u3059\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u73ed\u7814\u7a76\u6210\u679c\u306e\u793e\u4f1a\u3078\u306e\u9084\u5143\u3092\u56f3\u308b\u3002<\/p>\n

\n\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee
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\n\u2460 \u79fb\u690d\u5f8c100\u65e5\u6642\u70b9\u3067\u306e\u751f\u5b58
\n\u2461 \u30c9\u30ca\u30fc\u578b\u5b8c\u5168\u30ad\u30e1\u30e9\u306e\u9054\u6210 (\u79fb\u690d\u5f8cday 90\u00b15\u306e\u6642\u70b9\u3067donor\u7531\u6765\u7d30\u80de\u304c90%\u4ee5\u4e0a)<\/p>\n

\n\u526f\u6b21\u7684\u8a55\u4fa1\u9805\u76ee
\n\u79fb\u690d\u5f8c\uff11\u5e74\u306e\u751f\u5b58\u7387\u304a\u3088\u3073\u7121\u75c5\u751f\u5b58\u7387<\/p>\n

2-2-1\u524d\u51e6\u7f6e\u306e\u6bd2\u6027(\u79fb\u690d\u5f8c20\u65e5\u4ee5\u5185\u3001\u4ed8\u88684\u53c2\u7167)
\n2-2-2GVHD\u306e\u983b\u5ea6\u30fb\u91cd\u75c7\u5ea6\u306e\u691c\u8a0e(\u4ed8\u88683\u53c2\u7167)
\n2-2-3\u9020\u8840\u56de\u5fa9\u307e\u3067\u306e\u671f\u9593\u3001\u5b8c\u5168\u30ad\u30e1\u30e9\u9054\u6210\u307e\u3067\u306e\u671f\u9593
\n2-2-4\u79fb\u690d\u5f8c\u306e\u514d\u75ab\u80fd\u56de\u5fa9(CD4\/8\/19\u967d\u6027\u7d30\u80de\u3001IgG\/A\/M\u5b9a\u91cf)
\n2-2-5\u8853\u524d\u7642\u6cd5\u306b\u7528\u3044\u308b\u85ac\u5264\u306e\u85ac\u7269\u52d5\u614b
\n2-2-6DLI\u306b\u3088\u308b\u79fb\u690d\u7247\u62d2\u7d76\u306e\u9632\u6b62\u3001\u6297\u816b\u760d\u52b9\u679c
\n2-2-8\u75be\u60a3\u3054\u3068\u306e\u751f\u5b58\u7387\u3001\u7121\u75c5\u751f\u5b58\u7387(CML\u306b\u304a\u3044\u3066\u306fbcr\/abl mRNA\u306e\u8a55\u4fa1\u3092\u542b\u3080)<\/p>\n

\n\u8a66\u9a13\u85ac\u5264
\n\u672c\u7814\u7a76\u306b\u5bfe\u3057\u3066\u306f\u3001\u65e5\u672c\u30b7\u30a8\u30fc\u30ea\u30f3\u30b0\u793e\u304b\u3089\u30ea\u30f3\u9178\u30d5\u30eb\u30c0\u30e9\u30d3\u30f3\u304c\u7121\u511f\u4f9b\u4e0e\u3055\u308c\u308b\u3002\u3053\u306e\u85ac\u5264\u306f\u56fd\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u4e2d\u592e\u75c5\u9662\u85ac\u5264\u90e8\u3067\u4fdd\u7ba1\u3057\u3001\u75c7\u4f8b\u6bce\u306b\u51b7\u8535\u5b85\u6025\u4fbf\u3092\u7528\u3044\u3066\u5404\u65bd\u8a2d\u306b\u914d\u5e03\u3059\u308b\u3002<\/p>\n

\n\u9069\u683c\u6761\u4ef6
\n\u672c\u7814\u7a76\u306e\u5bfe\u8c61\u306f\u3001\u53c2\u52a0\u65bd\u8a2d\u306b\u304a\u3044\u3066\u6cbb\u7642\u3092\u53d7\u3051\u308b\u60a3\u8005\u306e\u3046\u3061\u3001\u4ed6\u306e\u6cbb\u7642\u3067\u306f\u6cbb\u7652\u3084\u9577\u671f\u751f\u5b58\u306e\u78ba\u7387\u304c\u4f4e\u3044\u3088\u3046\u306a\u75c5\u6c17\u3084\u75c5\u72b6\u3067\u3042\u308a\u3001\u540c\u7a2e\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u306e\u9069\u5fdc\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u72b6\u614b\u306b\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u9ad8\u9f62\u3067\u3042\u308b\u304c\u305f\u3081\u306b\u901a\u5e38\u306e\u8840\u7e01\/\u975e\u8840\u7e01\u8005\u9593\u540c\u7a2e\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u306e\u9069\u5fdc\u306b\u306a\u3089\u306a\u3044\u60a3\u8005\u3068\u3059\u308b\u3002\u8840\u6e05\u5b66\u691c\u67fb\u306b\u304a\u3044\u3066\u3001HLA\u306eA\/B\/DR\u5ea7\u304c\u5b8c\u5168(\uff16\u5ea7)\u4e00\u81f4\u306e\u540c\u80de\u30c9\u30ca\u30fc\u3092\u6709\u3057\u3001\u8aac\u660e\u540c\u610f\u66f8\u3092\u7528\u3044\u3066\u540c\u610f\u3092\u5f97\u305f\u8005\u306b\u3064\u3044\u3066\u884c\u3046\u3002
\n\u305f\u3060\u3057\u3001\u767b\u9332\u306f\u4eee\u767b\u9332\u3068\u672c\u767b\u9332\u306e\u4e8c\u6bb5\u968e\u306b\u5206\u3051\u3066\u884c\u3046\u3002\u3059\u306a\u308f\u3061\u3001\u60a3\u8005\u304b\u3089\u6587\u66f8\u3067\u540c\u610f\u3092\u53d6\u308a\u3001\u4eee\u767b\u9332\u524d\uff12\u9031\u9593\u4ee5\u5185\u306b\u5fc5\u8981\u306a\u691c\u67fb\u3092\u5b9f\u65bd\u3057\u30014-1-1\uff5e4-1-3\u304a\u3088\u30734-2\u306b\u793a\u3059\u4eee\u767b\u9332\u306b\u5fc5\u8981\u306a\u6761\u4ef6\u3092\u3059\u3079\u3066\u6e80\u305f\u3059\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\u4e0a\u3067\u4eee\u767b\u9332\u3092\u884c\u3044\u3001\u30c9\u30ca\u30fc\u306e\u672b\u68a2\u8840\u5e79\u7d30\u80de\u306e\u63a1\u53d6\u30fb\u51cd\u7d50\u4fdd\u5b58\u3092\u884c\u3046\u3002\u5f8c\u8ff0\u3059\u308b\u5fc5\u8981\u91cf\u306e\u5e79\u7d30\u80de\u304c\u5f97\u3089\u308c\u305f\u5834\u5408\u3001\u672c\u767b\u9332\u524d1\u9031\u9593\u4ee5\u5185\u306b\u5fc5\u8981\u306a\u691c\u67fb\u3092\u5b9f\u65bd\u3057\u30014-5\u306b\u793a\u3059\u672c\u767b\u9332\u306b\u304a\u3051\u308b\u9664\u5916\u6761\u4ef6\u3092\u78ba\u8a8d\u3057\u305f\u4e0a\u3067\u3001\u672c\u767b\u9332\u3092\u884c\u3046\u3002\u30c9\u30ca\u30fc\u304b\u3089\u5341\u5206\u306a\u5e79\u7d30\u80de\u91cf\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u5834\u5408\u3001\u3042\u308b\u3044\u306f\u672c\u767b\u9332\u306b\u304a\u3051\u308b\u9664\u5916\u6761\u4ef6\u306b\u8a72\u5f53\u3057\u305f\u5834\u5408\u3067\u3001\u4eee\u767b\u9332\u5f8c\u306e\u4e0d\u9069\u683c\u75c7\u4f8b\u3068\u5224\u65ad\u3055\u308c\u305f\u5834\u5408\u306b\u3064\u3044\u3066\u3082\u3001\u5fc5\u305a\u3001\u672c\u767b\u9332\u3092\u884c\u308f\u306a\u3044\u65e8\u3001\u304a\u3088\u3073\u305d\u306e\u7406\u7531\u3092\u30c7\u30fc\u30bf\u30bb\u30f3\u30bf\u30fc\u306b\u9023\u7d61\u3059\u308b\u3002\u306a\u304a\u3001\u524d\u51e6\u7f6e\u85ac\u306e\u6295\u4e0e\u306f\u3001\u672c\u767b\u9332\u5f8c1\u9031\u9593\u4ee5\u5185\u306b\u958b\u59cb\u3059\u308b\u3002<\/p>\n

4-1-1 \u4ee5\u4e0b\u306e\u3044\u305a\u308c\u304b\u306e\u75be\u60a3\u3092\u6709\u3059\u308b\u8005\u3002
\n\u6025\u6027\u9aa8\u9ac4\u6027\u30fb\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\uff08AML\u30fbALL\uff09\u306e\u7b2c\u4e00\u30fb\u7b2c\u4e8c\u5bdb\u89e3\u671f(\u4ed8\u88681\u53c2\u7167)
\n\u901a\u5e38\u306e\u5316\u5b66\u7642\u6cd5\u3067\u306e\u6cbb\u7652\u304c\u56f0\u96e3\u3068\u8003\u3048\u3089\u308c\u308b\u5834\u5408\u306b\u9650\u3089\u308c\u308b(\u4ed8\u88681\u53c2\u7167)\u3002
\n\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\uff08CML\uff09\u306e\u7b2c\u4e00\u30fb\u7b2c\u4e8c\u6162\u6027\u671f
\n\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306b\u3064\u3044\u3066\u306f\u30d2\u30c9\u30ed\u30ad\u30b7\u30a6\u30ec\u30a2\u306a\u3069\u306e\u6295\u4e0e\u306b\u3088\u308a\u672b\u68a2\u8840\u767d\u8840\u7403\u6570\u304c\uff11\u4e07\/\u03bcl\u4ee5\u4e0b\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u6761\u4ef6\u3068\u3059\u308b\u3002\u307e\u305f\u3001\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3084\u30a4\u30de\u30c1\u30cb\u30d6\u306b\u3088\u3063\u3066\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u5b8c\u5168\u5bdb\u89e3\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u75c7\u4f8b\u306f\u9664\u5916\u3059\u308b\u3002<\/p>\n

\u9aa8\u9ac4\u7570\u5f62\u6210\u75c7\u5019\u7fa4\uff08MDS\uff09\u306eFAB\u5206\u985e\u3067\u306eRA\u3001RARS\u3001RAEB
\nRA\u3001RARS\u306b\u3064\u3044\u3066\u306f\u597d\u4e2d\u7403500\/\u03bcl\u672a\u6e80\u3042\u308b\u3044\u306f\u8f38\u8840\u4f9d\u5b58\u6027\u306e\u75c7\u4f8b\u306b\u9650\u5b9a\u3059\u308b\u3002RAEB\u306b\u3064\u3044\u3066\u306f\u6297\u764c\u5264\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306a\u304f1\u30f6\u6708\u4ee5\u4e0aRAEB\u306e\u57fa\u6e96\u3092\u6e80\u305f\u3059\u72b6\u614b\u306b\u3042\u308b\u5b89\u5b9a\u3057\u305f\u75c7\u4f8b\u306b\u9650\u308b\u3002RAEB\u3001RAEB-t\u306b\u5bfe\u3057\u3066\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3063\u3066\u767d\u8840\u75c5\u7d30\u80de\u304c\u5341\u5206\u306b\u6e1b\u5c11\u3057\u305f\u75c7\u4f8b\u3082\u3001\u8a73\u7d30\u306e\u57fa\u6e96\u3092\u6e80\u305f\u305b\u3070\u9069\u683c\u3068\u3059\u308b\u3002
\n*RA=refractory anemia, RARS=RA with ringed sideloblast, RAEB=RA withexcess of blast<\/p>\n

4-1-2 \u4eee\u767b\u9332\u6642\u306e\u60a3\u8005\u306e\u5e74\u9f62\u304c50\u6b73\u4ee5\u4e0a70\u6b73\u672a\u6e80\u306e\u8005\u3002<\/p>\n

4-1-3 \u5065\u5eb7\u72b6\u614b\u304c\u826f\u597d\u3067\u3042\u308bHLA\u4e00\u81f4\u540c\u80de\u30c9\u30ca\u30fc\u3092\u6709\u3059\u308b\u8005\u3002\u5065\u5eb7\u72b6\u614b\u826f\u597d\u3068\u306f\u4ee5\u4e0b\u306e\u75be\u60a3\u3092\u6709\u3055\u306a\u3044\u3053\u3068\u3068\u5b9a\u7fa9\u3059\u308b\u3002\u30c9\u30ca\u30fc\u306e\u5e74\u9f62\u4e0a\u9650\u306b\u3064\u3044\u3066\u306f\u3001\u5404\u65bd\u8a2d\u306e\u502b\u7406\u59d4\u54e1\u4f1a\u3082\u3057\u304f\u306f\u305d\u308c\u306b\u6e96\u305a\u308b\u6a5f\u95a2\u306e\u5b9a\u3081\u305f\u5236\u9650\u306b\u5f93\u3046\u3002
\n(a) \u81ea\u5df1\u514d\u75ab\u75be\u60a3(\u81a0\u539f\u75c5\u3092\u542b\u3080)\u306e\u73fe\u6709\u53ca\u3073\u65e2\u5f80
\n(b) \u9759\u8108\u8840\u6813\u75c7\u3001\u52d5\u8108\u786c\u5316\u6027\u75be\u60a3\u306e\u73fe\u6709
\n(c) \u865a\u8840\u6027\u5fc3\u75be\u60a3\u3001\u8133\u8840\u7ba1\u75c5\u5909\u306e\u73fe\u6709\u53ca\u3073\u65e2\u5f80
\n(d) \u60aa\u6027\u816b\u760d\u3001\u904e\u53bb\u306e\u6297\u764c\u5264\u306e\u6295\u4e0e\u6b74\u3001\u904e\u53bb\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u6b74
\n(e) \u85ac\u7269\u6cbb\u7642\u3092\u5fc5\u8981\u3068\u3059\u308b\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u306e\u73fe\u6709
\n(f) \u767d\u8840\u7403\u3001\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3001\u8840\u5c0f\u677f\u5024\u306e\u7570\u5e38
\n(g) \u305d\u306e\u4ed6\u4e3b\u6cbb\u533b\u304c\u672b\u68a2\u8840\u5e79\u7d30\u80de\u63a1\u53d6\u306b\u4e0d\u9069\u5f53\u3068\u8003\u3048\u308b\u5065\u5eb7\u72b6\u614b
\n\u305f\u3060\u3057\u30c9\u30ca\u30fc\u304b\u3089\u5fc5\u8981\u91cf\u306e\u672b\u68a2\u8840\u5e79\u7d30\u80de\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u5834\u5408\u306f\u3001\u4eee\u767b\u9332\u5f8c\u4e0d\u9069\u683c\u75c7\u4f8b\u3068\u5224\u65ad\u3057\u3001\u89e3\u6790\u304b\u3089\u9664\u5916\u3059\u308b\u3002<\/p>\n

\n4-2 \u9664\u5916\u57fa\u6e96
\n\u4ee5\u4e0b\u306b\u793a\u3059\u91cd\u7be4\u306a\u81d3\u5668\u6a5f\u80fd\u969c\u5bb3\u3092\u6301\u3064\u8005(\u30c9\u30ca\u30fc\u3082\u542b\u3080)\u306f\u767b\u9332\u6642\u306b\u4e0d\u9069\u683c\u3068\u5224\u65ad\u3057\u9664\u5916\u3059\u308b\u3002
\n(a)\u3000ECOG\u306eperformance status\u304c2\u4ee5\u4e0a(\u4ed8\u88682\u53c2\u7167)
\n(b) \u5fc3\u30a8\u30b3\u30fc\u306b\u3066\u3001\u5b89\u9759\u6642\u306e\u5fc3\u99c6\u51fa\u7387\u304c50%\u672a\u6e80
\n(c)\u3000\u9178\u7d20\u975e\u6295\u4e0e\u3067\u306e\u52d5\u8108\u8840\u6db2\u4e2d\u9178\u7d20\u98fd\u548c\u5ea6\u304c93%\u672a\u6e80
\n(d)\u3000\u8840\u6e05\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u5024\u304c2.0 mg\/dl\u4ee5\u4e0a
\n(e) \u7dcf\u30d3\u30ea\u30eb\u30d3\u30f3\u5024\u304c2.0 mg\/dl\u4ee5\u4e0a\u3042\u308b\u3044\u306fGOT\u5024\u304c\u6b63\u5e38\u4e0a\u9650\u306e4\u500d\u4ee5\u4e0a
\n(f) HIV\u6297\u4f53\u304c\u967d\u6027
\n(g) \u6d3b\u52d5\u6027\u306e\u611f\u67d3\u75c7\u3092\u6709\u3059\u308b
\n\uff08h\uff09 \u524d\u51e6\u7f6e\u7642\u6cd5\u306b\u7528\u3044\u308b\u85ac\u5264\u3001\u306a\u3089\u3073\u306b\u6025\u6027GVHD\u4e88\u9632\u306b\u7528\u3044\u308b\u85ac\u5264\u306b\u5bfe\u3057\u904e\u654f\u75c7\u306e\u65e2\u5f80\u306e\u3042\u308b\u60a3\u8005<\/p>\n

GVHD\u4e88\u9632\u65b9\u6cd5\u306e\u5272\u4ed8
\nGVHD\u4e88\u9632\u65b9\u6cd5\u306f\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u5358\u5264\u306b\u3088\u308b\u65b9\u6cd5\u3068\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3068\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u3092\u4f75\u7528\u3057\u305f\u65b9\u6cd5\u306e\u5404\u7fa4\u306b30\u75c7\u4f8b\u306e\u7121\u4f5c\u70ba\u306a\u5272\u4ed8\u3092\u884c\u3046\u3002
\n\u306a\u304a\u30012\u7fa4\u9593\u306e\u6bd4\u8f03\u53ef\u80fd\u6027\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u3001\u57fa\u790e\u75be\u60a3\uff08\u6025\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u3001\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u3001\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u3001\u9aa8\u9ac4\u7570\u5f62\u6210\u75c7\u5019\uff09\u3001\u65bd\u8a2d\u3001\u5e74\u9f62\uff0850\uff5e59\u6b73\u300160\uff5e69\u6b73\uff09\u3001\u6027\u5225\uff08\u7537\u3001\u5973\uff09\u3092\u5272\u308a\u4ed8\u3051\u56e0\u5b50\u3068\u3057\u3066\u52d5\u7684\u306a\u5272\u4ed8\u3092\u884c\u3046\u3002<\/p>\n

GVHD\u306e\u4e88\u9632
\n1 \u3044\u305a\u308c\u306e\u7fa4\u3082\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3(CSA)\u306e\u6295\u4e0e\u3092\u884c\u3046\u3002CSA 3 mg\/kg\/day\u306e\u6301\u7d9a\u6295\u4e0e\u3092day-1\u304b\u3089\u958b\u59cb\u3059\u308b\u3002
\n2 Day 28\u3092\u904e\u304e\u305f\u6642\u70b9\u3067GVHD\u306e\u75c7\u72b6\u304c\u306a\u3051\u308c\u307010%\/\u9031\u3092\u76ee\u5b89\u306b\u6e1b\u91cf\u3057\u3001day 100\u9803\u307e\u3067\u306b\u4e2d\u6b62\u3059\u308b\u3002
\n3 \u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3068\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8\u306e\u4f75\u7528\u7fa4\u3067\u306f\u3001\u30e1\u30c8\u30c8\u30ec\u30ad\u30b5\u30fc\u30c8 10 mg\/m2\u3092day 1\u306b\u30017 mg\/m2\u3092day 3\u304a\u3088\u3073day 6\u306b\u3001\u305d\u308c\u305e\u308c\u7de9\u5f90\u9759\u6ce8\u3042\u308b\u3044\u306f30\u5206\u3067\u70b9\u6ef4\u9759\u6ce8\u3059\u308b\u3002\u30ed\u30a4\u30b3\u30dc\u30ea\u30f3\u306b\u3088\u308b\u6551\u63f4\u7642\u6cd5\u306f\u4f75\u7528\u3057\u306a\u3044\u3002<\/p>\n

\u4ed8\u8868\uff11\u3000\u6025\u6027\u767d\u8840\u75c5\u306e\u7b2c\u4e00\u5bdb\u89e3\u671f\u79fb\u690d\u306e\u9069\u5fdc\u306b\u3064\u3044\u3066
\n\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306b\u3064\u3044\u3066\u306f\u3001\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u5316\u5b66\u7642\u6cd5\u5358\u72ec\u3067\u306e\u6cbb\u7642\u6210\u7e3e\u306f\u6975\u3081\u3066\u4e0d\u826f\u3067\u3042\u308a\u3001\u5168\u75c7\u4f8b\u304c\u7b2c\u4e00\u5bdb\u89e3\u671f\u3067\u306e\u79fb\u690d\u9069\u5fdc\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u6025\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306b\u3064\u3044\u3066\u306f\u78ba\u56fa\u305f\u308b\u57fa\u6e96\u306f\u306a\u3044\u304c\u3001\u672c\u7814\u7a76\u3067\u306fJapan Adult Leukemia Study Group\u3067\u63a1\u7528\u3057\u3066\u3044\u308b\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0\u306b\u57fa\u3065\u304d\u3001t(8;21)\u3001t(15;17)\u3001inv(16)\u306e3\u3064\u306e\u67d3\u8272\u4f53\u7570\u5e38\u306e\u3069\u308c\u304b\u3092\u6301\u3064\u75c7\u4f8b\u4ee5\u5916\u306e\u7b2c\u4e00\u5bdb\u89e3\u671f\u75c7\u4f8b\u306f\u5168\u3066\u5bfe\u8c61\u3068\u3059\u308b\u3002\u307e\u305f\u3053\u308c\u3089\u306e\u67d3\u8272\u4f53\u7570\u5e38\u3092\u6301\u3064\u75c7\u4f8b\u306b\u304a\u3044\u3066\u3082\u3001\u4ee5\u4e0b\u306e\u6761\u4ef6\u306b\u4e00\u3064\u4ee5\u4e0a\u8a72\u5f53\u3059\u308b\u5834\u5408\u306b\u306f\u7b2c\u4e00\u5bdb\u89e3\u671f\u306e\u79fb\u690d\u9069\u5fdc\u3068\u8003\u3048\u308b\u3002
\n\u30fb\u767d\u8840\u75c5\u7d30\u80de\u306emyeloperoxidase\u967d\u6027\u7387\u304c50%\u4ee5\u4e0b
\n\u30fb\u521d\u767a\u6642\u767d\u8840\u7403\u304c20,000 \/\u03bcl \u4ee5\u4e0a
\n\u30fbFAB subtype\u304cM0,M6,M7
\n\u30fb\u5bdb\u89e3\u5c0e\u5165\u307e\u3067\u306b\uff12\u30b3\u30fc\u30b9\u4ee5\u4e0a\u3092\u5fc5\u8981\u3068\u3057\u305f\u3002<\/p>\n

http:\/\/www.h.u-tokyo.ac.jp\/mukin\/mini-prot.htm<\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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“\u539a\u751f\u52b4\u50cd\u7701\u73ed\u7814\u7a76 \u30df\u30cb\u79fb\u690d\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-24","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/24","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24"}],"version-history":[{"count":0,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/24\/revisions"}],"wp:attachment":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}