\u518d\u767a\u6027\u306e\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3068\u3073\u307e\u3093\u6027\u5927\u7d30\u80deB\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306bCMC-544\u304c\u6709\u671b\u3010EHA2010\u3011
\n\u68ee\u4e0b\u7d00\u4ee3\u7f8e\uff1d\u533b\u5b66\u30e9\u30a4\u30bf\u30fc <\/p>\n
\u5b66\u4f1a\u30b9\u30da\u30b7\u30e3\u30eb\uff1a\u7b2c15\u56de\u6b27\u5dde\u8840\u6db2\u5b66\u4f1a
\n2010\u5e746\u670810\u65e5\uff5e13\u65e5\u3000Barcelona, Spain <\/p>\n
\u30d9\u30eb\u30ae\u30fcUZ Leuven\u306eGregor Verhoef\u6c0f<\/p>\n
\u3000\u6297CD22\u30d2\u30c8\u5316\u6297\u4f53\u88fd\u5264\u306eCMC-544\uff08inotuzumab ozogamicin\uff09\u306f\u3001\u518d\u767a\u6027\u306e\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08FL\uff09\u3068\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b\uff08DLBCL\uff09\u306b\u304a\u3044\u3066\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3068\u306e\u4f75\u7528\u3067\u826f\u597d\u306a\u5168\u594f\u52b9\u7387\uff08ORR\uff09\u3068\u7121\u5897\u60aa\u751f\u5b58\u7387\uff08PFS\uff09\u3092\u793a\u3057\u3001\u8840\u6db2\u6bd2\u6027\u3084\u809d\u6a5f\u80fd\u4f4e\u4e0b\u306a\u3069\u306e\u6709\u5bb3\u4e8b\u8c61\u3082\u7ba1\u7406\u53ef\u80fd\u306a\u7bc4\u56f2\u306e\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u3001\u30d5\u30a7\u30fc\u30ba1\/2\u8a66\u9a13\u306e\u7d50\u679c\u3001\u793a\u3055\u308c\u305f\u30026\u670810\u65e5\u304b\u308913\u65e5\u307e\u3067\u30b9\u30da\u30a4\u30f3\u30fb\u30d0\u30eb\u30bb\u30ed\u30ca\u3067\u958b\u50ac\u3055\u308c\u305f\u6b27\u5dde\u8840\u6db2\u5b66\u4f1a\u3067\u3001\u30d9\u30eb\u30ae\u30fcUZ Leuven\u306eGregor Verhoef\u6c0f\u304c\u767a\u8868\u3057\u305f\u3002<\/p>\n
\u3000CMC-544\uff08inotuzumab ozogamicin\uff09\u306f\u3001\u5f37\u529b\u306a\u6297\u816b\u760d\u7269\u8cea\u306e\u30ab\u30ea\u30b1\u30a2\u30de\u30a4\u30b7\u30f3\u3092\u7d50\u5408\u3055\u305b\u305f\u6297CD22\u30d2\u30c8\u5316\u6297\u4f53\u88fd\u5264\u3002<\/p>\n
\u3000CD22\u306f\u3001B\u7d30\u80de\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\uff08NHL\uff09\u306e\u307b\u3068\u3093\u3069\u306b\u767a\u73fe\u3059\u308b\u3002CMC-544\u306fNHL\u3067\u6cbb\u7642\u6b74\u304c\u3042\u308b\u60a3\u8005\u3068\u6cbb\u7642\u4e0d\u5fdc\u6027\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u6700\u5927\u8010\u7528\u91cf\uff08MTD\uff09\u306f1.8mg\/m2\u3067\u3042\u308b\u3053\u3068\u3001\u5358\u5264\u3067\u826f\u597d\u306a\u6709\u52b9\u6027\u3068\u5fcd\u5bb9\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u30d5\u30a7\u30fc\u30ba1\u8a66\u9a13\u306e\u7d50\u679c\u304b\u3089\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n
\u3000Verhoef\u6c0f\u3089\u306f\u3001\u518d\u767a\u6027\u306eFL\u3001\u518d\u767a\u6027\u306eDLBCL\u3001\u6cbb\u7642\u4e0d\u5fdc\u6027\u3067\u300c\u9032\u884c\u6027\u300d\u306eNHL\u306a\u3069\u306eNHL\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3068\u306e\u4f75\u7528\u3067CMC-544\u306e\u81e8\u5e8a\u7684\u306a\u6d3b\u6027\u3092\u8a55\u4fa1\u3059\u308b\u30d5\u30a7\u30fc\u30ba1\/2\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u3002<\/p>\n
\u3000\u8a66\u9a13\u306f2\u3064\u306e\u30d1\u30fc\u30c8\u3067\u69cb\u6210\u3055\u308c\u3001\u30d1\u30fc\u30c81\u3067\u306f\u5897\u91cf\u6cd5\u3067MTD\u3092\u78ba\u8a8d\u3057\u305f\u3002\u30d1\u30fc\u30c82\u3067\u306fMTD\u3067\u30b3\u30db\u30fc\u30c8\u3092\u62e1\u5927\u3057\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306b\u3088\u308b\u524d\u6cbb\u7642\u3092\u53d7\u3051\u305fCD20\u967d\u6027\u304a\u3088\u3073CD22\u967d\u6027\u306eB\u7d30\u80deNHL\u60a3\u8005\u306b\u304a\u3051\u308b\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n
\u3000111\u4eba\u304c\u767b\u9332\u3055\u308c\u3001FL\u7fa438\u4eba\uff08\u5e74\u9f62\u4e2d\u592e\u502463.5\u6b73\uff09\u3001DLBCL\u7fa443\u4eba\uff08\u540c72\u6b73\uff09\u3001\u6cbb\u7642\u4e0d\u5fdc\u6027\u306eNHL\u7fa430\u4eba\uff08\u540c63\u6b73\uff09\u3068\u306a\u3063\u305f\u3002<\/p>\n
\u3000FL\u7fa4\u3068DLBCL\u7fa4\u306e\u60a3\u8005\u304c\u53d7\u3051\u305f\u524d\u6cbb\u7642\u306f2\u56de\u4ee5\u4e0b\u3067\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3092\u542b\u3080\u6cbb\u7642\u306b\u4e0d\u5fdc\u6027\u306e\u60a3\u8005\u306f\u542b\u307e\u306a\u304b\u3063\u305f\u3002\u6cbb\u7642\u4e0d\u5fdc\u6027\u306eNHL\u7fa4\u306b\u306f\u3001DLBCL\u3001\u30de\u30f3\u30c8\u30eb\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u3001\u5f62\u8cea\u8ee2\u63db\u3092\u4f34\u3046FL\u306a\u3069\u3092\u542b\u307f\u3001\u524d\u6cbb\u7642\u306e\u56de\u6570\u306f\u5236\u9650\u3057\u306a\u304b\u3063\u305f\u30023\u56de\u4ee5\u4e0a\u524d\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306e\u5272\u5408\u306f60\uff05\u3001\u524d\u6cbb\u7642\u3067\u9032\u884c\uff08PD\uff09\u3068\u306a\u3063\u305f\u60a3\u8005\u306f77\uff05\u3067\u3001\u4ed6\u306e2\u7fa4\u3068\u6bd4\u3079\u3066\u9ad8\u304b\u3063\u305f\u30023\u7fa4\u3068\u308270\uff05\u4ee5\u4e0a\u304c\u30b9\u30c6\u30fc\u30b8III\u307e\u305f\u306fIV\u306e\u60a3\u8005\u3067\u3042\u3063\u305f\u3002<\/p>\n
\u3000\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306fday1\u306b375mg\/m2\u3092\u3001CMC-544\u306fday2\u306b0.8 mg\/m2\u30011.3 mg\/m2\u30011.8mg\/m2\u306e3\u6bb5\u968e\u306e\u7528\u91cf\u3067\u6295\u4e0e\u3057\u300128\u65e5\u30921\u30b5\u30a4\u30af\u30eb\u3068\u3057\u3066\u3001PD\u3068\u306a\u3089\u306a\u3051\u308c\u30708\u30b5\u30a4\u30af\u30eb\u307e\u3067\u7d99\u7d9a\u3057\u305f\u3002<\/p>\n
\u3000\u5168\u60a3\u8005\u306e\u30b5\u30a4\u30af\u30eb\u6570\u306e\u4e2d\u592e\u5024\u306f4.0\u3067\u3001FL\u7fa45.5\u3001DLBCL\u7fa45.0\u3001\u6cbb\u7642\u4e0d\u5fdc\u6027\u306eNHL\u7fa42.0\u3067\u3042\u3063\u305f\u3002\u5168\u60a3\u8005\u306e\u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f16.0\u30ab\u6708\u3067\u3001FL\u7fa421.2\u30ab\u6708\u3001DLBCL\u7fa416.0\u30ab\u6708\u3001\u6cbb\u7642\u4e0d\u5fdc\u6027\u306eNHL\u7fa45.1\u30ab\u6708\u3067\u3042\u3063\u305f\u3002<\/p>\n
\u3000\u5168\u60a3\u8005\u306e10\uff05\u306b\u85ac\u5264\u95a2\u9023\u6027\u306e\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u304c\u767a\u73fe\u3057\u305f\u3002\u5168\u60a3\u8005\u306e15\uff05\u4ee5\u4e0a\u306b\u767a\u73fe\u3057\u305f\u30b0\u30ec\u30fc\u30c93\u307e\u305f\u306f4\u306e\u85ac\u5264\u95a2\u9023\u6027\u306e\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u75c731\uff05\u3001\u597d\u4e2d\u7403\u6e1b\u5c11\u75c718\uff05\u3067\u3042\u3063\u305f\u3002\u809d\u6a5f\u80fd\u4f4e\u4e0b\u306f\u307b\u3068\u3093\u3069\u304c\u30b0\u30ec\u30fc\u30c91\u307e\u305f\u306f2\u3067\u3001AST\u4e0a\u6607\uff0835\uff05\uff09\u3001\u9ad8\u30d3\u30ea\u30eb\u30d3\u30f3\u8840\u75c7\uff0825\uff05\uff09\u306a\u3069\u304c\u591a\u304f\u767a\u73fe\u3057\u305f\u3002<\/p>\n
\u3000MTD\u306b\u304a\u3051\u308b\u5b8c\u5168\u5bdb\u89e3\uff08CR\uff09\u3068\u90e8\u5206\u5bdb\u89e3\uff08PR\uff09\u3092\u5408\u308f\u305b\u305f\u5168\u594f\u52b9\u7387\uff08ORR\uff09\u306f\u3001FL\u7fa484\uff05\u3001DLBLC\u7fa480\uff05\u3067\u3042\u3063\u305f\u304c\u3001\u6cbb\u7642\u4e0d\u5fdc\u6027\u306eNHL\u7fa4\u3067\u306f18\uff05\u3067\u3042\u3063\u305f\u3002<\/p>\n
\u3000PFS\u306e\u4e2d\u592e\u5024\u306f\u3001FL\u7fa4\u3067\u306f\u5230\u9054\u3057\u3066\u304a\u3089\u305a\u3001DLBCL\u7fa415.6\u30ab\u6708\u3001\u6cbb\u7642\u4e0d\u5fdc\u6027\u306eNHL\u7fa41.8\u30ab\u6708\u3067\u3042\u3063\u305f\u3002<\/p>\n
\u30001\u5e74\u5168\u751f\u5b58\u7387\uff08OS\uff09\u306f\u3001FL\u7fa495\uff05\u3001DLBCL\u7fa480\uff05\u3001\u6cbb\u7642\u4e0d\u5fdc\u6027\u306eNHL\u7fa4\u3067\u306f\u5230\u9054\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u3002<\/p>\n
\u3000\u5f62\u8cea\u8ee2\u63db\u3092\u4f34\u3046FL\u3068DLBCL\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u524d\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u594f\u52b9\u306b\u3088\u308aPFS\u306f\u9855\u8457\u306b\u7570\u306a\u308a\u3001\u4e88\u5f8c\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002CR\u3092\u9054\u6210\u3057\u305f28\u4eba\u306ePFS\u306e\u4e2d\u592e\u5024\u306f17.1\u30ab\u6708\u3001PR\u307e\u305f\u306f\u5b89\u5b9a\uff08SD\uff09\u3060\u3063\u305f18\u4eba\u3067\u306f6.8\u30ab\u6708\u3001PD\u3068\u306a\u3063\u305f19\u4eba\u3067\u306f1.7\u30ab\u6708\u3067\u3042\u3063\u305f\u3002<\/p>\n
\u3000\u30ab\u30ea\u30b1\u30a2\u30de\u30a4\u30b7\u30f3\u306e\u7dcf\u91cf\u3067\u6e2c\u5b9a\u3057\u305fCMC-544\u306e\u6700\u9ad8\u8840\u6e05\u6fc3\u5ea6\u306f\u6cbb\u7642\u30b5\u30a4\u30af\u30eb\u3092\u901a\u3057\u3066\u307b\u307c\u540c\u7b49\u306761.0\uff5e71.1ng\/ml\u3067\u63a8\u79fb\u3057\u305f\u304c\u3001AUC\u306f\u30b5\u30a4\u30af\u30eb\u3092\u91cd\u306d\u308b\u3054\u3068\u306b\u5897\u52a0\u3057\u305f\u3002\u534a\u6e1b\u671f\u30821\u30b5\u30a4\u30af\u30eb\u4ee5\u5f8c\u306b\u5ef6\u9577\u3057\u305f\u30023\u30b5\u30a4\u30af\u30eb\u76ee\u4ee5\u5f8c\u3001\u66dd\u9732\u306e\u30d4\u30fc\u30af\u3068AST\u4e0a\u6607\u3001\u9ad8\u30d3\u30ea\u30eb\u30d3\u30f3\u8840\u75c7\u306e\u767a\u73fe\u306f\u76f8\u95a2\u3057\u305f\u3002<\/p>\n
\u3000Verhoef\u6c0f\u306f\u300c\u4eca\u56de\u5f97\u3089\u308c\u305f\u7d50\u679c\u306f\u3001\u81e8\u5e8a\u306b\u304a\u3051\u308bCMC-544\u306e\u958b\u767a\u306e\u7d99\u7d9a\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u300d\u3068\u8a71\u3057\u305f\u3002<\/p>\n
\n\u8a73\u3057\u304f\u306f
\nhttp:\/\/medical.nikkeibp.co.jp\/leaf\/all\/gakkai\/sp\/eha2010\/201006\/515583.html<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
\u6297CD22\u30d2\u30c8\u5316\u6297\u4f53\u88fd\u5264\u306eCMC-544\uff08inotuzumab ozogamicin\uff09\u306f\u3001\u518d\u767a\u6027\u306e\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08FL\uff09\u3068\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b\uff08DLBCL\uff09\u306b\u304a\u3044\u3066\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3068\u306e\u4f75\u7528\u3067\u826f\u597d\u306a\u5168\u594f\u52b9\u7387\uff08ORR\uff09\u3068\u7121\u5897\u60aa\u751f\u5b58\u7387\uff08PFS\uff09\u3092\u793a\u3057\u3001\u8840\u6db2\u6bd2\u6027\u3084\u809d\u6a5f\u80fd\u4f4e\u4e0b\u306a\u3069\u306e\u6709\u5bb3\u4e8b\u8c61\u3082\u7ba1\u7406\u53ef\u80fd\u306a\u7bc4\u56f2\u306e\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u3001\u30d5\u30a7\u30fc\u30ba1\/2\u8a66\u9a13\u306e\u7d50\u679c\u3001\u793a\u3055\u308c\u305f\u30026\u670810\u65e5\u304b\u308913\u65e5\u307e\u3067\u30b9\u30da\u30a4\u30f3\u30fb\u30d0\u30eb\u30bb\u30ed\u30ca\u3067\u958b\u50ac\u3055\u308c\u305f\u6b27\u5dde\u8840\u6db2\u5b66\u4f1a\u3067\u3001\u30d9\u30eb\u30ae\u30fcUZ Leuven\u306eGregor Verhoef\u6c0f\u304c\u767a\u8868\u3057\u305f\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-254","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=254"}],"version-history":[{"count":0,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/254\/revisions"}],"wp:attachment":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}