B\u7d30\u80de\u6027\u306e\u30ea\u30f3\u30d1\u816b\u306b\u5bfe\u3059\u308bDA-EPOCH-R\u7642\u6cd5\u306ePFS\u306f\u4ed6\u306e\u9ad8\u7528\u91cf\u5316\u5b66\u7642\u6cd5\u3068\u540c\u7b49<\/p>\n
\u68ee\u4e0b\u7d00\u4ee3\u7f8e\uff1d\u533b\u5b66\u30e9\u30a4\u30bf\u30fc\u3010ASH2011\u3011<\/p>\n
\u3000\u30b9\u30da\u30a4\u30f3\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7PETHEMA\u306b\u3088\u308b\u30d5\u30a7\u30fc\u30ba4\u306edose-adjusted\uff08DA\uff09-EPOCH-R\u8a66\u9a13\u304b\u3089\u3001DA-EPOCH-R\u7642\u6cd5\uff08\u30a8\u30c8\u30dd\u30b7\u30c9\u3001\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u3001\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3001\u30d7\u30ec\u30c9\u30cb\u30be\u30f3\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\uff09\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u306e\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u6027B\u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08DLBCL\uff09\u3067\u6cbb\u7642\u6b74\u304c\u306a\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u6709\u671b\u306a\u8ee2\u5e30\u3092\u793a\u3057\u3001\u6bd2\u6027\u3082\u53d7\u5bb9\u53ef\u80fd\u306a\u7bc4\u56f2\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u6210\u679c\u306f\u300112\u670810\u65e5\u304b\u308913\u65e5\u307e\u3067\u7c73\u56fd\u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\u3067\u958b\u50ac\u3055\u308c\u305f\u7b2c53\u56de\u7c73\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH2011\uff09\u3067\u3001\u30b9\u30da\u30a4\u30f3Hospital Universitari Vall d\u2019Hebron\u306eNoelia Purroy\u6c0f\u304c\u767a\u8868\u3057\u305f\u3002<\/p>\n
\u3000B\u7d30\u80de\u6027\u306e\u30ea\u30f3\u30d1\u816b\u306b\u5bfe\u3059\u308bDA-EPOCH\u7642\u6cd5\u306f\u3001\u521d\u671f\u6cbb\u7642\u3067\u826f\u597d\u306a\u5b8c\u5168\u5bdb\u89e3\u7387\uff08CR\uff09\u30685\u5e74\u306e\u7121\u5897\u60aa\u751f\u5b58\u7387\uff08PFS\uff09\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3068DA-EPOCH\u7642\u6cd5\u306e\u4f75\u7528\u3082\u6709\u671b\u3068\u306e\u5831\u544a\u304c\u3042\u308b\u3002
\n\u3000
\n\u3000\u524d\u5411\u304d\u3001\u591a\u65bd\u8a2d\u5171\u540c\u3001\u30d5\u30a7\u30fc\u30ba4\u306eDA-EPOCH-R\u8a66\u9a13\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u306eB\u7d30\u80de\u6027\u306e\u30ea\u30f3\u30d1\u816b\u3067\u6cbb\u7642\u6b74\u304c\u306a\u3044\u60a3\u8005\u306b\u304a\u3051\u308bPFS\u3001\u526f\u6b21\u7684\u306a\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u5168\u751f\u5b58\u7387\uff08OS\uff09\u3001\u5b8c\u5168\u5bdb\u89e3\uff08CR\uff09\u3001\u6bd2\u6027\u306e\u8a55\u4fa1\u3067\u3042\u308b\u3002<\/p>\n
\u3000\u5e74\u9f62\u8abf\u6574\u56fd\u969b\u4e88\u5f8c\u6307\u6a19\uff08aaIPI\uff09\u304c1\u4ee5\u4e0a\u307e\u305f\u306fIPI\u304c2\u4ee5\u4e0a\u3001II\uff5eIV\u671f\u3067\u3001\u6cbb\u7642\u6b74\u304c\u306a\u3044\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001DA-EPOCH-R\u7642\u6cd5\u30923\u30b5\u30a4\u30af\u30eb\u884c\u3063\u305f\u3002\u4e0d\u5909\u3001\u9032\u884c\u3057\u305f\u60a3\u8005\u3092\u5bfe\u8c61\u304b\u3089\u9664\u5916\u3057\u3001\u5b8c\u5168\u5bdb\u89e3\uff08CR\uff09\u307e\u305f\u306f\u90e8\u5206\u5bdb\u89e3\uff08PR\uff09\u3068\u306a\u3063\u305f\u60a3\u8005\u306b\u3055\u3089\u306b3\u30b5\u30a4\u30af\u30eb\u884c\u3063\u305f\u3002\u958b\u59cb\u6642\u306e\u7528\u91cf\u3068\u3057\u3066\u3001\u30a8\u30c8\u30dd\u30b7\u30c950mg\/m2\/\u65e5\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f310mg\/m2\/\u65e5\u3001\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f30.4mg\/m2\u30921\u304b\u30894\u65e5\u76ee\u306b\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6375mg\/m2\u30921\u65e5\u76ee\u306b\u3001\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9750mg\/m2\u30925\u65e5\u76ee\u306b\u3001\u30d7\u30ec\u30c9\u30cb\u30be\u30f360mg\/m2\/\u65e5\u30921\u304b\u30895\u65e5\u76ee\u306b\u6295\u4e0e\u3057\u305f\u3002<\/p>\n
\u3000DA-EPOCH-R\u7642\u6cd5\u306e\u7528\u91cf\u306e\u8abf\u6574\u306f\u3001\u30b5\u30a4\u30af\u30eb\u7d42\u4e86\u304b\u308910\u304b\u308915\u65e5\u5f8c\u306b\u597d\u4e2d\u7403\u7d76\u5bfe\u6570\uff08ANC\uff09\u3068\u8840\u5c0f\u677f\u6570\u3092\u6e2c\u5b9a\u3057\u3001ANC\u22670.5\u00d7109\/L\u306e\u5834\u5408\u3001\u30a8\u30c8\u30dd\u30b7\u30c9\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3001\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9\u3092\u5f8c\u534a\u306e\u30b5\u30a4\u30af\u30eb\u306e\u524d\u306b20\uff05\u5897\u91cf\u3057\u305f\u3002ANC\uff1c0.5\u00d7109\/L\u304c4\u65e5\u9593\u4ee5\u4e0a\u6301\u7d9a\u3001\u8840\u5c0f\u677f\u6570\uff1c25\u00d7109\u3001\u767a\u71b1\u6027\u306e\u597d\u4e2d\u7403\u6e1b\u5c11\u306e\u5834\u5408\u306f\u3001\u3053\u308c\u3089\u306e3\u5264\u309220\uff05\u6e1b\u91cf\u3057\u305f\u3002<\/p>\n
\u3000\u5168\u4f8b\u306b\u9846\u7c92\u7403\u30b3\u30ed\u30cb\u30fc\u523a\u6fc0\u56e0\u5b50\uff08G-CSF\uff09\u3092\u6295\u4e0e\u3057\u305f\u3002\u6b8b\u5b58\u75c5\u5909\u3092\u8a8d\u3081\u308b\u5834\u5408\u306f\u653e\u5c04\u7dda\u7642\u6cd5\u3092\u8ffd\u52a0\u3057\u305f\u3002\u8ffd\u8de1\u306f3\u30ab\u6708\u3054\u3068\u306b2\u5e74\u9593\u3001\u305d\u306e\u5f8c6\u30ab\u6708\u3054\u3068\u306b3\u5e74\u9593\u884c\u3063\u305f\u3002<\/p>\n
\u300081\u4eba\uff08\u5e74\u9f62\u4e2d\u592e\u502460\u6b73\u3001\u7537\u602748.1\uff05\uff09\u304c\u767b\u9332\u3055\u308c\u305f\u3002Ann Arbor\u5206\u985e\u306eIII\uff5eIV\u671f\u306e\u60a3\u8005\u304c91.1\uff05\u3060\u3063\u305f\u3002\u4e2d\u9ad8\u30ea\u30b9\u30af\u3001\u9ad8\u30ea\u30b9\u30af\u306e\u60a3\u8005\u306f\u3001IPI\u306784\uff05\u3001aaIPI\u306792.5\uff05\u3068\u306a\u3063\u305f\u3002\u75be\u60a3\u306e\u5185\u8a33\u306f\u3001DLBCL\u304c68\u4eba\uff0884\uff05\uff09\u3001\u539f\u767a\u6027\u7e26\u9694\u5927\u7d30\u80de\u578bB\u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b \uff08PMLBL\uff1aPrimary mediastinal large B cell lymphoma\uff09\u304c6\u4eba\uff087.2\uff05\uff09\u3001\u30b0\u30ec\u30fc\u30c93\u306e\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u304c7\u4eba\uff088.4\uff05\uff09\u3060\u3063\u305f\u3002<\/p>\n
\u3000\u76f8\u5bfe\u7684\u7528\u91cf\uff08relative dose\uff09\u306e\u4e2d\u592e\u5024\u306f\u30ec\u30d9\u30eb1\uff08100\uff05\uff09\uff5e\u30ec\u30d9\u30eb6\uff08240\uff05\uff09\u306e\u4e2d\u306e\u30ec\u30d9\u30eb3\uff08144\uff05\uff09\u3001\u6295\u4e0e\u30b5\u30a4\u30af\u30eb\u306e\u4e2d\u592e\u5024\u306f6\u3060\u3063\u305f\u3002<\/p>\n
\u3000\u5b8c\u5168\u5bdb\u89e3\u307e\u305f\u306f\u4e0d\u78ba\u5b9a\u5b8c\u5168\u5bdb\u89e3\u306f65\u4eba\u3067\u5f97\u3089\u308c\u3001CR\u306f80.2\uff05\u3068\u306a\u3063\u305f\u3002IPI\u304c3\uff5e5\u306e\u60a3\u8005\u3067\u306f75\uff05\u3060\u3063\u305f\u3002
\n\u3000
\n\u30005\u5e74\u306ePFS\u306f62\uff05\u3068\u306a\u308a\u3001\u4ed6\u306e\u9ad8\u7528\u91cf\u306e\u30ec\u30b8\u30e1\u30f3\u3068\u540c\u7b49\u306e\u6709\u52b9\u6027\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002OS\u306f67\uff05\u3001\u7121\u518d\u767a\u751f\u5b58\u7387\uff08DFS\uff09\u306f72.2\uff05\u3068\u306a\u3063\u305f\u3002<\/p>\n
\u3000\u6bd2\u6027\u306b\u3064\u3044\u3066\u3001\u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306e\u8ca7\u8840\u306f\u60a3\u8005\u306e84\uff05\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u306f71.6\uff05\u306b\u767a\u73fe\u3057\u305f\u3002\u767a\u71b1\u6027\u306e\u597d\u4e2d\u7403\u6e1b\u5c11\u306f45.7\uff05\u306b\u767a\u73fe\u3057\u305f\u3002\u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306e\u7c98\u819c\u708e\u306f11.1\uff05\u3001\u795e\u7d4c\u6bd2\u6027\u306f2.5\uff05\u306b\u767a\u73fe\u3057\u305f\u3002<\/p>\n
\u3000Purroy\u6c0f\u306f\u3001\u300c\u9ad8\u30ea\u30b9\u30af\u306eDLBCL\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3059\u308b\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001R-CHOP\u7642\u6cd5\u3068DA-EPOCH\u7642\u6cd5\u3092\u6bd4\u8f03\u3057\u691c\u8a3c\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u300d\u3068\u8a71\u3057\u305f\u3002<\/p>\n
\nhttp:\/\/medical.nikkeibp.co.jp\/leaf\/all\/gakkai\/sp\/ash2011\/201112\/522905.html&cnavi=1<\/p>\n","protected":false},"excerpt":{"rendered":"
B\u7d30\u80de\u6027\u306e\u30ea\u30f3\u30d1\u816b\u306b\u5bfe\u3059\u308bDA-EPOCH-R\u7642\u6cd5\u306ePFS\u306f\u4ed6\u306e\u9ad8\u7528\u91cf\u5316\u5b66\u7642\u6cd5\u3068\u540c\u7b49
\n\u68ee\u4e0b\u7d00\u4ee3\u7f8e\uff1d\u533b\u5b66\u30e9\u30a4\u30bf\u30fc\u3010ASH2011\u3011
\n\u3000\u30b9\u30da\u30a4\u30f3\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7PETHEMA\u306b\u3088\u308b\u30d5\u30a7\u30fc\u30ba4\u306edose-adjusted\uff08DA\uff09-EPOCH-R\u8a66\u9a13\u304b\u3089\u3001DA-EPOCH-R\u7642\u6cd5\uff08\u30a8\u30c8\u30dd\u30b7\u30c9\u3001\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u3001\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3001\u30d7\u30ec\u30c9\u30cb\u30be\u30f3\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\uff09\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u306e\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u6027B\u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08DLBCL\uff09\u3067\u6cbb\u7642\u6b74\u304c\u306a\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u6709\u671b\u306a\u8ee2\u5e30\u3092\u793a\u3057\u3001\u6bd2\u6027\u3082\u53d7\u5bb9\u53ef\u80fd\u306a\u7bc4\u56f2\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u6210\u679c\u306f\u300112\u670810\u65e5\u304b\u308913\u65e5\u307e\u3067\u7c73\u56fd\u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\u3067\u958b\u50ac\u3055\u308c\u305f\u7b2c53\u56de\u7c73\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH2011\uff09\u3067\u3001\u30b9\u30da\u30a4\u30f3Hospital Universitari Vall d\u2019Hebron\u306eNoelia Purroy\u6c0f\u304c\u767a\u8868\u3057\u305f\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-276","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=276"}],"version-history":[{"count":0,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/276\/revisions"}],"wp:attachment":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}