\u5168\u8eab\u816b\u760d\u7d44\u7e54\u91cf\u304c\u5c11\u306a\u3044\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3067\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306e\u30e1\u30f3\u30c6\u30ca\u30f3\u30b9\u7642\u6cd5\u3068\u518d\u767a\u30fb\u9032\u884c\u6642\u306e\u518d\u6cbb\u7642\u306f\u6cbb\u7642\u6210\u529f\u671f\u9593\u304c\u540c\u7b49\u306b\u826f\u597d<\/p>\n
\u68ee\u4e0b\u7d00\u4ee3\u7f8e\uff1d\u533b\u5b66\u30e9\u30a4\u30bf\u30fc\u3010ASH2011\u3011<\/p>\n
\n\u3000\u6cbb\u7642\u6b74\u304c\u306a\u3044\u5168\u8eab\u816b\u760d\u7d44\u7e54\u91cf\u304c\u5c11\u306a\u3044\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08FL\uff09\u306b\u5bfe\u3057\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306b\u3088\u308b\u30e1\u30f3\u30c6\u30ca\u30f3\u30b9\u7642\u6cd5\uff08maintenance rituximab\uff1aMR\uff09\u3068\u518d\u767a\u30fb\u9032\u884c\u6642\u306e\u518d\u6cbb\u7642\uff08rituximab retreatment\uff1aRR\uff09\u306e\u6cbb\u7642\u6210\u529f\u671f\u9593\uff08TTTF\uff09\u306f\u540c\u7b49\u306b\u826f\u597d\u3068\u306a\u308b\u3053\u3068\u304c\u3001ECOG\u306eE4402\uff08RESORT\uff09\u8a66\u9a13\u304b\u3089\u793a\u3055\u308c\u305f\u300212\u67088\u65e5\u304b\u308913\u65e5\u307e\u3067\u7c73\u56fd\u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\u3067\u958b\u50ac\u3055\u308c\u305f\u7b2c53\u56de\u7c73\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH2011\uff09\u3067\u3001\u7c73University of Wisconsin\u306eBrad S. Kahl\u6c0f\u304c\u767a\u8868\u3057\u305f\u3002<\/p>\n
\u3000\u5168\u8eab\u816b\u760d\u7d44\u7e54\u91cf\u304c\u5c11\u306a\u3044FL\u3067\u306f\u3001\u816b\u760d\u7d44\u7e54\u91cf\u304c\u5897\u52a0\u3057\u3066\u304b\u3089\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308bWatch and wait\u304c\u6a19\u6e96\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u305f\u3002\u8fd1\u5e74\u3067\u306f\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306e\u6709\u52b9\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002<\/p>\n
\u3000Kahl\u6c0f\u3089\u306f\u3001\u3053\u306e\u3088\u3046\u306aFL\u60a3\u8005\u3067\u306f\u300c\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306b\u3088\u308b\u5c0e\u5165\u7642\u6cd5\u65bd\u884c\u5f8c\u306eMR\u306f\u3001RR\u3068\u6bd4\u8f03\u3057\u3066\u75c5\u52e2\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b\u300d\u3068\u306e\u4eee\u8aac\u3092\u305f\u3066\u3001E4402\uff08RESORT\uff09\u8a66\u9a13\u3067\u691c\u8a3c\u3057\u305f\u3002
\n\u3000
\n\u3000\u3053\u306e\u8a66\u9a13\u3067\u306f\u3001\u5c0e\u5165\u7642\u6cd5\u3068\u3057\u3066\u30ea\u30c4\u30ad\u30b7\u30de\u30d6375mg\/m2\u3092\u6bce\u9031\u30014\u30b5\u30a4\u30af\u30eb\u6295\u4e0e\u3057\u3001\u5b8c\u5168\u5bdb\u89e3\uff08CR\uff09\u307e\u305f\u306f\u90e8\u5206\u5bdb\u89e3\uff08PR\uff09\u304c\u5f97\u3089\u308c\u305f\u60a3\u8005\u3092\u3001\u30e1\u30f3\u30c6\u30ca\u30f3\u30b9\u7642\u6cd5\u3068\u3057\u3066\u30ea\u30c4\u30ad\u30b7\u30de\u30d6375mg\/m2\u30923\u30ab\u6708\u6bce\u306b\u6295\u4e0e\u3059\u308b\u7fa4\uff08MR\u7fa4\uff09\u3068\u3001\u9032\u884c\u6642\u306e\u518d\u6cbb\u7642\u3068\u3057\u3066\u30ea\u30c4\u30ad\u30b7\u30de\u30d6375mg\/m2\u3092\u6bce\u9031\u30014\u30b5\u30a4\u30af\u30eb\u6295\u4e0e\u3059\u308b\u7fa4\uff08RR\u7fa4\uff09\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002\u6cbb\u7642\u4e0d\u6210\u529f\u3068\u5224\u65ad\u3055\u308c\u308b\u307e\u3067\u6295\u4e0e\u3092\u7d99\u7d9a\u3057\u305f\u3002
\n\u3000
\n\u3000\u8a66\u9a13\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u6cbb\u7642\u6210\u529f\u671f\u9593\uff08TTTF\uff09\u3060\u3063\u305f\u3002
\n\u3000
\n\u30002003\u5e7411\u6708\u304b\u30892008\u5e749\u6708\u307e\u3067\u306b545\u4eba\u304c\u767b\u9332\u3055\u308c\u3001FL\u60a3\u8005\u306f384\u4eba\u3060\u3063\u305f\u3002274\u4eba\u304c\u5c0e\u5165\u7642\u6cd5\u3067\u5bdb\u89e3\u3057\u3001MR\u7fa4\u306b140\u4eba\uff08\u5e74\u9f62\u4e2d\u592e\u502458.9\u6b73\u3001\u7537\u602754\uff05\uff09RR\u7fa4\u306b134\u4eba\uff08\u540c59.5\u6b73\u3001\u7537\u602754\uff05\uff09\u304c\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u60a3\u8005\u80cc\u666f\u306f\u4e21\u7fa4\u3067\u307b\u307c\u540c\u69d8\u3067\u3001\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u306e\u56fd\u969b\u4e88\u5f8c\u6307\u6a19\uff08FLIPI\uff09\u3067\u9ad8\u30ea\u30b9\u30af\u306e\u60a3\u8005\u306e\u5272\u5408\u306f\u305d\u308c\u305e\u308c41\uff05\u306839\uff05\u3060\u3063\u305f\u3002<\/p>\n
\u3000\u7121\u4f5c\u70ba\u5316\u6642\u306eCR\u306f\u3001MR\u7fa418\uff05\u3001RR\u7fa414\uff05\u3001PR\u306f\u305d\u308c\u305e\u308c78\uff05\u306881\uff05\u3060\u3063\u305f\u3002
\n\u3000
\n\u3000\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306eTTTF\u306f\u3001MR\u7fa43.9\u5e74\u3001RR\u7fa43.6\u5e74\u3068\u306a\u308a\u3001\u6709\u610f\u5dee\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\uff08p=0.80\uff09\u3002\u5f93\u6765\u306e\u65b9\u6cd5\u3068\u6bd4\u8f03\u3057\u3066\u826f\u597d\u306a\u7d50\u679c\u3068\u306a\u3063\u305f\u3002\u6cbb\u7642\u4e0d\u6210\u529f\u306e\u5185\u8a33\u306f\u3001MR\u7fa4\u3067\u306f\u540c\u610f\u306e\u64a4\u56de\u304c\u6700\u3082\u591a\u304f\uff0826\u4eba\uff09\u3001\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\uff08TTP\uff096\u30ab\u6708\u672a\u6e80\uff0825\u4eba\uff09\u304c\u3053\u308c\u306b\u6b21\u3044\u3060\u3002RR\u7fa4\u3067\u306f\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u62b5\u6297\u6027\uff0818\u4eba\uff09\u304c\u6700\u3082\u591a\u304f\u3001\u540c\u610f\u306e\u64a4\u56de\uff0816\u4eba\uff09\u304c\u3053\u308c\u306b\u6b21\u3044\u3060\u3002
\n\u3000
\n\u30003\u5e74\u306e\u6642\u70b9\u3067\u5316\u5b66\u7642\u6cd5\u306b\u3088\u308b\u6cbb\u7642\u3092\u958b\u59cb\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u306e\u306f\u3001MR\u7fa495\uff05\u3001RR\u7fa486\uff05\u306b\u4e0a\u3063\u305f\uff08p=0.03\uff09\u3002
\n\u3000
\n\u3000\u5c0e\u5165\u7642\u6cd5\u306e4\u56de\u3092\u52a0\u3048\u305f\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306e\u6295\u4e0e\u56de\u6570\uff08\u4e2d\u592e\u5024\uff09\u306f\u3001MR\u7fa415.8\u3001RR\u7fa44.5\u3060\u3063\u305f\u3002MR\u7fa4\u3067\u304b\u304b\u308b\u8cbb\u7528\u306fRR\u7fa4\u306e3.5\u500d\u4ee5\u4e0a\u3068\u306a\u3063\u305f\u3002\u307e\u305f\u3001\u7121\u4f5c\u70ba\u5316\u304b\u30891\u5e74\u5f8c\u306e\u60a3\u8005\u306eQOL\u306b\u5909\u5316\u306f\u89b3\u5bdf\u3055\u308c\u306a\u304b\u3063\u305f\u3002
\n\u3000
\n\u3000\u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306e\u6bd2\u6027\u306e\u767a\u73fe\u306f\u4e21\u7fa4\u3068\u3082\u306b\u4f4e\u304f\u30015\uff05\u672a\u6e80\u3060\u3063\u305f\u3002\u4e8c\u6b21\u6027\u306e\u816b\u760d\u306f\u3001MR\u7fa47\u4eba\u3001RR\u7fa49\u4eba\u306b\u767a\u73fe\u3057\u305f\u3002
\n\u3000
\n\u3000Kahl\u6c0f\u306f\u3001\u8ee2\u5e30\u304c\u826f\u597d\u3067\u3001\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u73fe\u7387\u304c\u4f4e\u304f\u3001\u6295\u4e0e\u56de\u6570\u304c\u5c11\u306a\u3044\u3053\u3068\u306a\u3069\u3092\u6839\u62e0\u3068\u3057\u3066\u3001\u300c\u5168\u8eab\u816b\u760d\u7d44\u7e54\u91cf\u304c\u5c11\u306a\u3044FL\u60a3\u8005\u306b\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u5358\u5264\u306e\u6cbb\u7642\u3092\u9078\u629e\u3059\u308b\u5834\u5408\u3001RR\u3092\u63a8\u5968\u3059\u308b\u300d\u3068\u8a71\u3057\u305f\u3002<\/p>\n
\nhttp:\/\/medical.nikkeibp.co.jp\/leaf\/all\/gakkai\/sp\/ash2011\/201112\/522906.html&cnavi=1<\/p>\n
\u3000<\/p>\n","protected":false},"excerpt":{"rendered":"
\u5168\u8eab\u816b\u760d\u7d44\u7e54\u91cf\u304c\u5c11\u306a\u3044\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3067\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306e\u30e1\u30f3\u30c6\u30ca\u30f3\u30b9\u7642\u6cd5\u3068\u518d\u767a\u30fb\u9032\u884c\u6642\u306e\u518d\u6cbb\u7642\u306f\u6cbb\u7642\u6210\u529f\u671f\u9593\u304c\u540c\u7b49\u306b\u826f\u597d
\n\u68ee\u4e0b\u7d00\u4ee3\u7f8e\uff1d\u533b\u5b66\u30e9\u30a4\u30bf\u30fc\u3010ASH2011\u3011
\n\u3000\u6cbb\u7642\u6b74\u304c\u306a\u3044\u5168\u8eab\u816b\u760d\u7d44\u7e54\u91cf\u304c\u5c11\u306a\u3044\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08FL\uff09\u306b\u5bfe\u3057\u3001\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306b\u3088\u308b\u30e1\u30f3\u30c6\u30ca\u30f3\u30b9\u7642\u6cd5\uff08maintenance rituximab\uff1aMR\uff09\u3068\u518d\u767a\u30fb\u9032\u884c\u6642\u306e\u518d\u6cbb\u7642\uff08rituximab retreatment\uff1aRR\uff09\u306e\u6cbb\u7642\u6210\u529f\u671f\u9593\uff08TTTF\uff09\u306f\u540c\u7b49\u306b\u826f\u597d\u3068\u306a\u308b\u3053\u3068\u304c\u3001ECOG\u306eE4402\uff08RESORT\uff09\u8a66\u9a13\u304b\u3089\u793a\u3055\u308c\u305f\u300212\u67088\u65e5\u304b\u308913\u65e5\u307e\u3067\u7c73\u56fd\u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\u3067\u958b\u50ac\u3055\u308c\u305f\u7b2c53\u56de\u7c73\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH2011\uff09\u3067\u3001\u7c73University of Wisconsin\u306eBrad S. Kahl\u6c0f\u304c\u767a\u8868\u3057\u305f\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-277","post","type-post","status-publish","format-standard","hentry","category-4"],"_links":{"self":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=277"}],"version-history":[{"count":0,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/277\/revisions"}],"wp:attachment":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}