{"id":38,"date":"2008-01-01T00:00:00","date_gmt":"2007-12-31T15:00:00","guid":{"rendered":"http:\/\/haruko.km2m.net\/2008\/01\/01\/%e9%ab%98%e9%bd%a2%e8%80%85%e3%81%ae%e3%81%b3%e3%81%be%e3%82%93%e6%80%a7%e5%a4%a7%e7%b4%b0%e8%83%9e%e5%9e%8bb%e7%b4%b0%e8%83%9e%e6%80%a7%e3%83%aa%e3%83%b3%e3%83%91%e8%85%ab%e4%be%8b%e3%81%ab%e5%af%be\/"},"modified":"2008-01-01T00:00:00","modified_gmt":"2007-12-31T15:00:00","slug":"%e9%ab%98%e9%bd%a2%e8%80%85%e3%81%ae%e3%81%b3%e3%81%be%e3%82%93%e6%80%a7%e5%a4%a7%e7%b4%b0%e8%83%9e%e5%9e%8bb%e7%b4%b0%e8%83%9e%e6%80%a7%e3%83%aa%e3%83%b3%e3%83%91%e8%85%ab%e4%be%8b%e3%81%ab%e5%af%be","status":"publish","type":"post","link":"https:\/\/haruko.km2m.net\/?p=38","title":{"rendered":"\u9ad8\u9f62\u8005\u306e\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b\u4f8b\u306b\u5bfe\u3059\u308bCHOP14\u306b\u30ea\u30c4\u30ad\u30b5\u30f3\u4f75\u7528 2008\u5e74"},"content":{"rendered":"

\u9ad8\u9f62\u8005\u306eCD20\u967d\u6027B\u7d30\u80de\u6027aggressive lymphoma\u306b\u5bfe\u3059\u308b6\u307e\u305f\u306f8\u30b3\u30fc\u30b9\u306eCHOP14\u306b\u30ea\u30c4\u30ad\u30b5\u30f3\u4f75\u7528\u306e\u6709\u7121\u306b\u5bfe\u3059\u308b\u7121\u4f5c\u70ba\u6bd4\u8f03\u8a66\u9a13\u3000(RICOVER-60) Lancet Oncol 9:105-16,2008 <\/p>\n

\uff08\u8003\u5bdf\uff09
\n6\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7642\u6cd5\u306f6\u30b3\u30fc\u30b9\u306eCHOP-14\u7642\u6cd5\u306b\u6bd4\u3079EFS\u3084PFS\u3084OS\u3092\u5927\u304d\u304f\u6539\u5584\u3055\u305b\u305f\u3002\u4eca\u56de\u306e\u691c\u8a0e\u3067\u306f\u6cbb\u7642\u53cd\u5fdc\u4f8b\u306b\u5bfe\u30576\u30b3\u30fc\u30b9\u5f8c\u306b\u5316\u5b66\u7642\u6cd5\u3092\u8ffd\u52a0\u3059\u308b\u5fc5\u8981\u6027\u306f\u306a\u304b\u3063\u305f\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u8a55\u4fa1\u3057\u305f4\u3064\u306eregimen\u3067\u30016\u30b3\u30fc\u30b9\u306eR-CHOP14\u7642\u6cd5\u306f\u9ad8\u9f62\u8005\u306e\u6cbb\u7642\u3068\u3057\u3066\u512a\u5148\u3055\u308c\u308b\u6cbb\u7642\u6cd5\u3067\u3042\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u305f\u3002<\/p>\n

\n\uff08\u306f\u3058\u3081\u306b\uff09
\nCHOP \uff08\u30b7\u30af\u30ed\u30d5\u30a9\u30b9\u30d5\u30a1\u30df\u30c9\u3001\u30a2\u30c9\u30ea\u30a2\u30de\u30a4\u30b7\u30f3\u3001\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u304a\u3088\u3073\u30d7\u30ec\u30c9\u30cb\u30f3\u4f75\u7528\uff09\u7642\u6cd5\u306f\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b(NHL)\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u3068\u3057\u3066\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002\u9ad8\u9f62\u8005\u306e\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b\u306e\u4e88\u5f8c\u306f21\u65e5\u6bce\u306bCHOP\u7642\u6cd5\u3092\u65bd\u884c\u3059\u308bCHOP-21\u7642\u6cd5\u306e\u6cbb\u7642\u671f\u9593\u309214\u65e5\u306b\u77ed\u7e2e\u3057\u305fCHOP-14\u7642\u6cd5\u3042\u308b\u3044\u306fCHOP-21\u7642\u6cd5\u306b\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3092\u4f75\u7528\u3057\u305fR-CHOP-21\u7642\u6cd5\u306e\u958b\u767a\u306b\u3088\u3063\u3066\u6539\u5584\u3057\u3066\u3044\u308b\u3002\u4eca\u56de\u306e\u7121\u4f5c\u70ba\u6bd4\u8f03\u8a66\u9a13\u3067\u306f\u9ad8\u9f62\u8005\u306e\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b\u4f8b\u306b\u5bfe\u3059\u308b6\u307e\u305f\u306f8\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7642\u6cd5\u30016\u307e\u305f\u306f8\u30b3\u30fc\u30b9\u306eCHOP-14\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n

\uff08\u65b9\u6cd5\uff09
\n1222 \u4f8b\u306e\u9ad8\u9f62\u8005(61-80\u6b73)\u75c7\u4f8b\u304c6\u307e\u305f\u306f8\u30b3\u30fc\u30b9\u306eCHOP-14\u7642\u6cd5\u306b\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3092\u4f75\u7528\u3059\u308b\u304b\u3057\u306a\u3044\u304b\u3092\u7121\u4f5c\u70ba\u306b\u5272\u308a\u3064\u3051\u305f\u3002\u653e\u5c04\u7dda\u7642\u6cd5\u306f\u7bc0\u5916\u6027\u75c5\u5909\u306e\u6709\u7121\u306b\u95a2\u4fc2\u306a\u304f\u8a3a\u65ad\u6642\u306e\u5de8\u5927\u75c5\u5909\u306b\u5bfe\u3057\u3066\u306f\u8a08\u753b\u3057\u305f\u3002\u4e3b\u8a55\u4fa1\u9805\u76ee\u306fevent free survival\uff08EFS)\u3001\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u52b9\u679c(response)\u3068\u6cbb\u7642\u4e2d\u306ePD(progression during treatment)\u3068PFS(progression-free survival)\u3068OS(overall survival)
\n\u3068\u6bd2\u6027\u983b\u5ea6\u306e\u8a55\u4fa1\u3067\u3042\u3063\u305f\u3002<\/p>\n

\n\uff08\u7d50\u679c\uff09
\n3 \u5e74\u306eEFS\u306f6\u30b3\u30fc\u30b9\u306eCHOP-14\u7fa4\u3067\u306f47.2\uff05\u3067\u30018\u30b3\u30fc\u30b9\u306eCHOP-14\u7fa4\u3067\u306f53.0\uff05\u3067\u30016\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7fa4\u3067\u306f66.5\uff05\u3067\u30018\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7fa4\u3067\u306f63.1\uff05\u3067\u3042\u3063\u305f\u30026\u30b3\u30fc\u30b9\u306eCHOP-14\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u30018\u30b3\u30fc\u30b9\u306eCHOP-14\u7fa4\u3067\u306f3\u5e74\u306eEFS\u304c5.8\uff05\u6539\u5584\u3057\u30016\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7fa4\u3067\u306f19.3\uff05\u6539\u5584\u3057\u30018\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7fa4\u3067\u306f15.9\uff05\u306e\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f\u30023\u5e74\u306eOS\u306f6\u30b3\u30fc\u30b9\u306eCHOP-14\u7fa4\u3067\u306f67.7\uff05\u30018\u30b3\u30fc\u30b9\u306eCHOP-14\u7fa4\u3067\u306f66.0\uff05\u30016\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7fa4\u3067\u306f78.1\uff05\u30018\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7fa4\u3067\u306f72.5\uff05\u3067\u3042\u3063\u305f\u30026\u30b3\u30fc\u30b9\u306eCHOP-14\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u30018\u30b3\u30fc\u30b9\u306eCHOP-14\u7fa4\u3067\u306fOS\u304c1.7\uff05\u4f4e\u4e0b\u3057\u30016\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7fa4OS\u306f10.4\uff05\u6539\u5584\u3057\u30018\u30b3\u30fc\u30b9\u306eR-CHOP-14\u7fa4\u3067\u306f4.8\uff05\u6539\u5584\u3092\u8a8d\u3081\u305f\u30026\u30b3\u30fc\u30b9\u306eCHOP-14\u7fa4\u3067\u306e\u591a\u5909\u91cf\u89e3\u6790\u3067\u5224\u660e\u3057\u305f\u4e88\u5f8c\u56e0\u5b50\u3067\u88dc\u6b63\u3057\u3066\u3082\u30013\u5e74\u306eEFS\u306f3\u7fa4\u3059\u3079\u30666\u30b3\u30fc\u30b9CHOP-14\u7fa4\u3088\u308a\u3082\u6709\u610f\u306b\u6539\u5584\u3057\u3066\u3044\u305f\u3002<\/p>\n

Progressio n-free survival(PFS)\u306f6\u30b3\u30fc\u30b9\u306eR-CHOP14\u7fa4\u30688\u30b3\u30fc\u30b9\u306eR-CHOP14\u7fa4\u3067\u6709\u610f\u306a\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002Overall survival(OS)\u306f6\u30b3\u30fc\u30b9\u306eR-CHOP\u7fa4\u3067\u306e\u307f\u6709\u610f\u306a\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f\u30024\u30b3\u30fc\u30b9\u5f8c\u306bPR\u306b\u9054\u3057\u305f\u75c7\u4f8b\u306e\u4e88\u5f8c\u306f\u8a088\u30b3\u30fc\u30b9\u306e\u6cbb\u7642\u3092\u884c\u3063\u3066\u30826\u30b3\u30fc\u30b9\u7fa4\u3092\u4e0a\u56de\u3089\u306a\u304b\u3063\u305f\u3002<\/p>\n

\n\u5bfa\u7530\u82b3\u6a39\uff08\u5e73\u621020\u5e743\u670810\u65e5 <\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u9ad8\u9f62\u8005\u306eCD20\u967d\u6027B\u7d30\u80de\u6027aggressive lymphoma\u306b\u5bfe\u3059\u308b6\u307e\u305f\u306f8\u30b3\u30fc\u30b9\u306eCHOP14\u306b\u30ea\u30c4\u30ad\u30b5\u30f3\u4f75\u7528\u306e\u6709\u7121\u306b\u5bfe\u3059\u308b\u7121\u4f5c\u70ba\u6bd4\u8f03\u8a66\u9a13\u3000(RICOVER-60) Lancet Oncol 9:105-16, … <\/p>\n

“\u9ad8\u9f62\u8005\u306e\u3073\u307e\u3093\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b\u4f8b\u306b\u5bfe\u3059\u308bCHOP14\u306b\u30ea\u30c4\u30ad\u30b5\u30f3\u4f75\u7528 2008\u5e74” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-38","post","type-post","status-publish","format-standard","hentry","category-6"],"_links":{"self":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/38","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=38"}],"version-history":[{"count":0,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=\/wp\/v2\/posts\/38\/revisions"}],"wp:attachment":[{"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=38"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=38"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haruko.km2m.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=38"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}